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The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice.
Reagan AM, Christensen KE, Graham LC, Bedwell AA, Eldridge K, Speedy R, Figueiredo LL, Persohn SC, Bottiglieri T, Nho K, Sasner M, Territo PR, Rozen R, Howell GR. Reagan AM, et al. Among authors: howell gr. J Cereb Blood Flow Metab. 2022 Dec;42(12):2333-2350. doi: 10.1177/0271678X221122644. Epub 2022 Sep 1. J Cereb Blood Flow Metab. 2022. PMID: 36050860 Free PMC article.
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. Jay TR, et al. Among authors: howell gr. J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2. J Exp Med. 2015. PMID: 25732305 Free PMC article.
Toward more predictive genetic mouse models of Alzheimer's disease.
Onos KD, Sukoff Rizzo SJ, Howell GR, Sasner M. Onos KD, et al. Among authors: howell gr. Brain Res Bull. 2016 Apr;122:1-11. doi: 10.1016/j.brainresbull.2015.12.003. Epub 2015 Dec 17. Brain Res Bull. 2016. PMID: 26708939 Free PMC article. Review.
A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.
Wang X, Philip VM, Ananda G, White CC, Malhotra A, Michalski PJ, Karuturi KRM, Chintalapudi SR, Acklin C, Sasner M, Bennett DA, De Jager PL, Howell GR, Carter GW. Wang X, et al. Among authors: howell gr. Genetics. 2018 May;209(1):51-64. doi: 10.1534/genetics.117.300673. Epub 2018 Mar 5. Genetics. 2018. PMID: 29507048 Free PMC article.
119 results