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Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao PC, Tsai LH, Haure-Mirande JV, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein HU; Accelerating Medicines Partnership-Alzheimer’s Disease Consortium; Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Ertekin-Taner N, Liu Z, Shulman JM, Mangravite LM, Logsdon BA. Wan YW, et al. Among authors: howell gr. Cell Rep. 2020 Jul 14;32(2):107908. doi: 10.1016/j.celrep.2020.107908. Cell Rep. 2020. PMID: 32668255 Free PMC article.
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. Jay TR, et al. Among authors: howell gr. J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2. J Exp Med. 2015. PMID: 25732305 Free PMC article.
Toward more predictive genetic mouse models of Alzheimer's disease.
Onos KD, Sukoff Rizzo SJ, Howell GR, Sasner M. Onos KD, et al. Among authors: howell gr. Brain Res Bull. 2016 Apr;122:1-11. doi: 10.1016/j.brainresbull.2015.12.003. Epub 2015 Dec 17. Brain Res Bull. 2016. PMID: 26708939 Free PMC article. Review.
A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.
Wang X, Philip VM, Ananda G, White CC, Malhotra A, Michalski PJ, Karuturi KRM, Chintalapudi SR, Acklin C, Sasner M, Bennett DA, De Jager PL, Howell GR, Carter GW. Wang X, et al. Among authors: howell gr. Genetics. 2018 May;209(1):51-64. doi: 10.1534/genetics.117.300673. Epub 2018 Mar 5. Genetics. 2018. PMID: 29507048 Free PMC article.
Exercise prevents obesity-induced cognitive decline and white matter damage in mice.
Graham LC, Grabowska WA, Chun Y, Risacher SL, Philip VM, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative (ADNI); Sukoff Rizzo SJ, Howell GR. Graham LC, et al. Among authors: howell gr. Neurobiol Aging. 2019 Aug;80:154-172. doi: 10.1016/j.neurobiolaging.2019.03.018. Epub 2019 May 3. Neurobiol Aging. 2019. PMID: 31170535 Free PMC article.
Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma.
Buchanan RA, Foley KE, Pepper KW, Reagan AM, Keezer KJ, Hewes AA, Diemler CA, Preuss C, Soto I, John SWM, Howell GR. Buchanan RA, et al. Among authors: howell gr. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3283-3296. doi: 10.1167/iovs.18-26126. Invest Ophthalmol Vis Sci. 2019. PMID: 31369031 Free PMC article.
119 results