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The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.
Sidobre S, Hammond KJ, Bénazet-Sidobre L, Maltsev SD, Richardson SK, Ndonye RM, Howell AR, Sakai T, Besra GS, Porcelli SA, Kronenberg M. Sidobre S, et al. Among authors: howell ar. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12254-9. doi: 10.1073/pnas.0404632101. Epub 2004 Aug 10. Proc Natl Acad Sci U S A. 2004. PMID: 15304644 Free PMC article.
Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.
Ndonye RM, Izmirian DP, Dunn MF, Yu KO, Porcelli SA, Khurana A, Kronenberg M, Richardson SK, Howell AR. Ndonye RM, et al. Among authors: howell ar. J Org Chem. 2005 Dec 9;70(25):10260-70. doi: 10.1021/jo051147h. J Org Chem. 2005. PMID: 16323834
Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation.
Blauvelt ML, Khalili M, Jaung W, Paulsen J, Anderson AC, Brian Wilson S, Howell AR. Blauvelt ML, et al. Among authors: howell ar. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6374-6. doi: 10.1016/j.bmcl.2008.10.086. Epub 2008 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18993065 Free PMC article.
A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.
Lombardi V, Stock P, Singh AK, Kerzerho J, Yang W, Sullivan BA, Li X, Shiratsuchi T, Hnatiuk NE, Howell AR, Yu KO, Porcelli SA, Tsuji M, Kronenberg M, Wilson SB, Akbari O. Lombardi V, et al. Among authors: howell ar. J Immunol. 2010 Feb 15;184(4):2107-15. doi: 10.4049/jimmunol.0901208. Epub 2010 Jan 18. J Immunol. 2010. PMID: 20083656 Free PMC article.
Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.
Tyznik AJ, Farber E, Girardi E, Birkholz A, Li Y, Chitale S, So R, Arora P, Khurana A, Wang J, Porcelli SA, Zajonc DM, Kronenberg M, Howell AR. Tyznik AJ, et al. Among authors: howell ar. Chem Biol. 2011 Dec 23;18(12):1620-30. doi: 10.1016/j.chembiol.2011.10.015. Chem Biol. 2011. PMID: 22195564 Free PMC article.
83 results