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Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.
Ndonye RM, Izmirian DP, Dunn MF, Yu KO, Porcelli SA, Khurana A, Kronenberg M, Richardson SK, Howell AR. Ndonye RM, et al. Among authors: howell ar. J Org Chem. 2005 Dec 9;70(25):10260-70. doi: 10.1021/jo051147h. J Org Chem. 2005. PMID: 16323834
Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.
Chennamadhavuni D, Saavedra-Avila NA, Carreño LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascón JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR. Chennamadhavuni D, et al. Among authors: howell ar. Cell Chem Biol. 2018 May 17;25(5):571-584.e8. doi: 10.1016/j.chembiol.2018.02.009. Epub 2018 Mar 22. Cell Chem Biol. 2018. PMID: 29576533 Free PMC article.
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.
Chandra S, Gray J, Kiosses WB, Khurana A, Hitomi K, Crosby CM, Chawla A, Fu Z, Zhao M, Veerapen N, Richardson SK, Porcelli SA, Besra G, Howell AR, Sharma S, Peters B, Kronenberg M. Chandra S, et al. Among authors: howell ar. Nat Commun. 2018 Oct 15;9(1):4279. doi: 10.1038/s41467-018-06646-8. Nat Commun. 2018. PMID: 30323255 Free PMC article.
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.
Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM, Henry CL, Richardson SK, Predovic M, Huang B, Dix MM, Howell AR, Niphakis MJ, Shannon K, Cravatt BF. Remsberg JR, et al. Among authors: howell ar. Nat Chem Biol. 2021 Aug;17(8):856-864. doi: 10.1038/s41589-021-00785-8. Epub 2021 Apr 29. Nat Chem Biol. 2021. PMID: 33927411 Free PMC article.
A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response.
Lameris R, Shahine A, Pellicci DG, Uldrich AP, Gras S, Le Nours J, Groen RWJ, Vree J, Reddiex SJJ, Quiñones-Parra SM, Richardson SK, Howell AR, Zweegman S, Godfrey DI, de Gruijl TD, Rossjohn J, van der Vliet HJ. Lameris R, et al. Among authors: howell ar. Nat Cancer. 2020 Nov;1(11):1054-1065. doi: 10.1038/s43018-020-00111-6. Epub 2020 Sep 14. Nat Cancer. 2020. PMID: 35122066
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.
Sidobre S, Hammond KJ, Bénazet-Sidobre L, Maltsev SD, Richardson SK, Ndonye RM, Howell AR, Sakai T, Besra GS, Porcelli SA, Kronenberg M. Sidobre S, et al. Among authors: howell ar. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12254-9. doi: 10.1073/pnas.0404632101. Epub 2004 Aug 10. Proc Natl Acad Sci U S A. 2004. PMID: 15304644 Free PMC article.
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