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Page 1
Donated chemical probes for open science.
Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A. Müller S, et al. Among authors: howe t. Elife. 2018 Apr 20;7:e34311. doi: 10.7554/eLife.34311. Elife. 2018. PMID: 29676732 Free PMC article.
The promise and peril of chemical probes.
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. Arrowsmith CH, et al. Among authors: howe t. Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. Nat Chem Biol. 2015. PMID: 26196764 Free PMC article.
Corrigendum: The promise and peril of chemical probes.
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. Arrowsmith CH, et al. Among authors: howe t. Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. Nat Chem Biol. 2015. PMID: 26485080 No abstract available.
A genetics-led approach defines the drug target landscape of 30 immune-related traits.
Fang H; ULTRA-DD Consortium; De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC. Fang H, et al. Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28. Nat Genet. 2019. PMID: 31253980 Free PMC article.
Design and synthesis of a library of chemokine antagonists.
Bhalay G, Albrecht B, Akhlaq M, Baettig U, Beer D, Brown Z, Charlton S, Dunstan A, Bradley M, Gedeck P, Glen A, Howe T, Keller T, Leighton-Davies J, Li A, McCarthy C, Mocquet C, Owen C, Nicklin P, Rosethorne E. Bhalay G, et al. Among authors: howe t. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6249-52. doi: 10.1016/j.bmcl.2011.09.013. Epub 2011 Sep 10. Bioorg Med Chem Lett. 2011. PMID: 21940167
8-Aryl xanthines potent inhibitors of phosphodiesterase 5.
Arnold R, Beer D, Bhalay G, Baettig U, Collingwood SP, Craig S, Devereux N, Dunstan A, Glen A, Gomez S, Haberthuer S, Howe T, Jelfs S, Moser H, Naef R, Nicklin P, Sandham D, Stringer R, Turner K, Watson S, Zurini M. Arnold R, et al. Among authors: howe t. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2587-90. doi: 10.1016/s0960-894x(02)00480-8. Bioorg Med Chem Lett. 2002. PMID: 12182866
New highly potent and selective adenosine A(3) receptor antagonists.
Press NJ, Keller TH, Tranter P, Beer D, Jones K, Faessler A, Heng R, Lewis C, Howe T, Gedeck P, Mazzoni L, Fozard JR. Press NJ, et al. Among authors: howe t. Curr Top Med Chem. 2004;4(8):863-70. doi: 10.2174/1568026043451023. Curr Top Med Chem. 2004. PMID: 15078217
340 results