Howard RJ - Search Results

1

Molecular Dynamics Simulations of Ion Channels.

Carnevale V, Delemotte L, Howard RJ. Carnevale V, et al. Among authors: howard rj. Trends Biochem Sci. 2021 Jul;46(7):621-622. doi: 10.1016/j.tibs.2021.04.005. Epub 2021 Apr 30. Trends Biochem Sci. 2021. PMID: 33941431 Free article. No abstract available.

2

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.

Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E. Brömstrup T, et al. Among authors: howard rj. Structure. 2013 Aug 6;21(8):1307-16. doi: 10.1016/j.str.2013.06.018. Epub 2013 Jul 25. Structure. 2013. PMID: 23891290 Free PMC article.

3

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA. Heusser SA, et al. Among authors: howard rj. Mol Pharmacol. 2013 Nov;84(5):670-8. doi: 10.1124/mol.113.087692. Epub 2013 Aug 15. Mol Pharmacol. 2013. PMID: 23950219 Free PMC article.

4

Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.

Howard RJ, Carnevale V, Delemotte L, Hellmich UA, Rothberg BS. Howard RJ, et al. Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):927-942. doi: 10.1016/j.bbamem.2017.12.013. Epub 2017 Dec 16. Biochim Biophys Acta Biomembr. 2018. PMID: 29258839 Free PMC article. Review.

5

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.

Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M. Fourati Z, et al. Among authors: howard rj. Cell Rep. 2018 Apr 24;23(4):993-1004. doi: 10.1016/j.celrep.2018.03.108. Cell Rep. 2018. PMID: 29694907 Free article.

6

Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity.

Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E. Heusser SA, et al. Among authors: howard rj. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10672-10677. doi: 10.1073/pnas.1809650115. Epub 2018 Oct 1. Proc Natl Acad Sci U S A. 2018. PMID: 30275330 Free PMC article.

7

Sharing Data from Molecular Simulations.

Abraham M, Apostolov R, Barnoud J, Bauer P, Blau C, Bonvin AMJJ, Chavent M, Chodera J, Čondić-Jurkić K, Delemotte L, Grubmüller H, Howard RJ, Jordan EJ, Lindahl E, Ollila OHS, Selent J, Smith DGA, Stansfeld PJ, Tiemann JKS, Trellet M, Woods C, Zhmurov A. Abraham M, et al. Among authors: howard rj. J Chem Inf Model. 2019 Oct 28;59(10):4093-4099. doi: 10.1021/acs.jcim.9b00665. Epub 2019 Oct 11. J Chem Inf Model. 2019. PMID: 31525920

8

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations.

Rovšnik U, Zhuang Y, Forsberg BO, Carroni M, Yvonnesdotter L, Howard RJ, Lindahl E. Rovšnik U, et al. Among authors: howard rj. Life Sci Alliance. 2021 Jul 1;4(8):e202101011. doi: 10.26508/lsa.202101011. Print 2021 Aug. Life Sci Alliance. 2021. PMID: 34210687 Free PMC article.

9

Elephants in the Dark: Insights and Incongruities in Pentameric Ligand-gated Ion Channel Models.

Howard RJ. Howard RJ. J Mol Biol. 2021 Aug 20;433(17):167128. doi: 10.1016/j.jmb.2021.167128. Epub 2021 Jul 3. J Mol Biol. 2021. PMID: 34224751 Free article. Review.

10

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.

Lycksell M, Rovšnik U, Bergh C, Johansen NT, Martel A, Porcar L, Arleth L, Howard RJ, Lindahl E. Lycksell M, et al. Among authors: howard rj. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2108006118. doi: 10.1073/pnas.2108006118. Proc Natl Acad Sci U S A. 2021. PMID: 34504004 Free PMC article.

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