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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Becker K, Cao S, Nilsson A, Erlandsson M, Hotop SK, Kuka J, Hansen J, Haldimann K, Grinberga S, Berruga-Fernández T, Huseby DL, Shariatgorji R, Lindmark E, Platzack B, Böttger EC, Crich D, Friberg LE, Vingsbo Lundberg C, Hughes D, Brönstrup M, Andrén PE, Liepinsh E, Hobbie SN. Becker K, et al. Among authors: hotop sk. EBioMedicine. 2021 Nov;73:103652. doi: 10.1016/j.ebiom.2021.103652. Epub 2021 Nov 2. EBioMedicine. 2021. PMID: 34740109 Free PMC article.
Subcellular Quantification of Uptake in Gram-Negative Bacteria.
Prochnow H, Fetz V, Hotop SK, García-Rivera MA, Heumann A, Brönstrup M. Prochnow H, et al. Among authors: hotop sk. Anal Chem. 2019 Feb 5;91(3):1863-1872. doi: 10.1021/acs.analchem.8b03586. Epub 2018 Dec 11. Anal Chem. 2019. PMID: 30485749
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