Hosseini I - Search Results

1

Systems-based digital twins to help characterize clinical dose-response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL.

Susilo ME, Li CC, Gadkar K, Hernandez G, Huw LY, Jin JY, Yin S, Wei MC, Ramanujan S, Hosseini I. Susilo ME, et al. Among authors: hosseini i. Clin Transl Sci. 2023 Jul;16(7):1134-1148. doi: 10.1111/cts.13501. Epub 2023 Mar 23. Clin Transl Sci. 2023. PMID: 36908269 Free PMC article. Clinical Trial.

2

gPKPDSim: a SimBiology^®-based GUI application for PKPD modeling in drug development.

Hosseini I, Gajjala A, Bumbaca Yadav D, Sukumaran S, Ramanujan S, Paxson R, Gadkar K. Hosseini I, et al. J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):259-275. doi: 10.1007/s10928-017-9562-9. Epub 2018 Jan 4. J Pharmacokinet Pharmacodyn. 2018. PMID: 29302838 Free PMC article.

3

gQSPSim: A SimBiology-Based GUI for Standardized QSP Model Development and Application.

Hosseini I, Feigelman J, Gajjala A, Susilo M, Ramakrishnan V, Ramanujan S, Gadkar K. Hosseini I, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Mar;9(3):165-176. doi: 10.1002/psp4.12494. Epub 2020 Mar 10. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 31957304 Free PMC article.

4

Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling.

Hosseini I, Gadkar K, Stefanich E, Li CC, Sun LL, Chu YW, Ramanujan S. Hosseini I, et al. NPJ Syst Biol Appl. 2020 Aug 28;6(1):28. doi: 10.1038/s41540-020-00145-7. NPJ Syst Biol Appl. 2020. PMID: 32859946 Free PMC article.

5

Quantitative Clinical Pharmacology of T-Cell Engaging Bispecifics: Current Perspectives and Opportunities.

Morcos PN, Li J, Hosseini I, Li CC. Morcos PN, et al. Among authors: hosseini i. Clin Transl Sci. 2021 Jan;14(1):75-85. doi: 10.1111/cts.12877. Epub 2020 Nov 18. Clin Transl Sci. 2021. PMID: 32882099 Free PMC article. Review.

6

Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.

Lu D, Yadav R, Holder P, Chiang E, Sanjabi S, Poon V, Bernett M, Varma R, Liu K, Leung I, Bogaert L, Desjarlais J, Shivva V, Hosseini I, Ramanujan S. Lu D, et al. Among authors: hosseini i. Eur J Pharm Sci. 2023 Jul 1;186:106450. doi: 10.1016/j.ejps.2023.106450. Epub 2023 Apr 20. Eur J Pharm Sci. 2023. PMID: 37084985 Free article.

7

Current practices for QSP model assessment: an IQ consortium survey.

Chan JR, Allen R, Boras B, Cabal A, Damian V, Gibbons FD, Gulati A, Hosseini I, Kearns JD, Saito R, Cucurull-Sanchez L, Selimkhanov J, Stein AM, Umehara K, Wang G, Wang W, Neves-Zaph S. Chan JR, et al. Among authors: hosseini i. J Pharmacokinet Pharmacodyn. 2022 Aug 11:1-13. doi: 10.1007/s10928-022-09811-1. Online ahead of print. J Pharmacokinet Pharmacodyn. 2022. PMID: 35953664 Free PMC article.

8

Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities.

Shemesh CS, Hsu JC, Hosseini I, Shen BQ, Rotte A, Twomey P, Girish S, Wu B. Shemesh CS, et al. Among authors: hosseini i. Mol Ther. 2021 Feb 3;29(2):555-570. doi: 10.1016/j.ymthe.2020.09.038. Epub 2020 Sep 30. Mol Ther. 2021. PMID: 33038322 Free PMC article. Review.

9

Tunable nanofluidic device for digital nucleic acid analysis.

Hosseini II, Hamidi SV, Capaldi X, Liu Z, Silva Pessoa MA, Mahshid S, Reisner W. Hosseini II, et al. Nanoscale. 2024 May 16;16(19):9583-9592. doi: 10.1039/d3nr05553a. Nanoscale. 2024. PMID: 38682564

10

Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.

Gampa G, Spinosa P, Getz J, Zhong Y, Halpern W, Esen E, Davies J, Chou C, Kwong M, Wang Y, Arenzana TL, Shivva V, Huseni M, Hsieh R, Schartner J, Koerber JT, Rutz S, Hosseini I. Gampa G, et al. Among authors: hosseini i. Br J Pharmacol. 2024 Mar 14. doi: 10.1111/bph.16326. Online ahead of print. Br J Pharmacol. 2024. PMID: 38486310

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