Hosmane RS - Search Results

1

Structure-based drug design and potent anti-cancer activity of tricyclic 5:7:5-fused diimidazo[4,5-d:4',5'-f][1,3]diazepines.

Kondaskar A, Kondaskar S, Fishbein JC, Carter-Cooper BA, Lapidus RG, Sadowska M, Edelman MJ, Hosmane RS. Kondaskar A, et al. Among authors: hosmane rs. Bioorg Med Chem. 2013 Feb 1;21(3):618-31. doi: 10.1016/j.bmc.2012.11.050. Epub 2012 Dec 11. Bioorg Med Chem. 2013. PMID: 23290252 Free PMC article.

2

A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system.

Xie M, Ujjinamatada RK, Sadowska M, Lapidus RG, Edelman MJ, Hosmane RS. Xie M, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4386-9. doi: 10.1016/j.bmcl.2010.06.061. Epub 2010 Jun 15. Bioorg Med Chem Lett. 2010. PMID: 20594843 Free PMC article.

3

A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibition.

Chakraborty S, Shah NH, Fishbein JC, Hosmane RS. Chakraborty S, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2011 Jan 15;21(2):756-9. doi: 10.1016/j.bmcl.2010.11.109. Epub 2010 Nov 27. Bioorg Med Chem Lett. 2011. PMID: 21183343 Free PMC article.

4

Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System.

Kondaskar A, Kondaskar S, Kumar R, Fishbein JC, Muvarak N, Lapidus RG, Sadowska M, Edelman MJ, Bol GM, Vesuna F, Raman V, Hosmane RS. Kondaskar A, et al. Among authors: hosmane rs. ACS Med Chem Lett. 2010 Dec 31;2(3):252-256. doi: 10.1021/ml100281b. ACS Med Chem Lett. 2010. PMID: 21572541 Free PMC article.

5

Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues.

Chakraborty S, Shah NH, Fishbein JC, Hosmane RS. Chakraborty S, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7214-8. doi: 10.1016/j.bmcl.2012.09.053. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084905 Free PMC article.

6

Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.

Tantravedi S, Chakraborty S, Shah NH, Fishbein JC, Hosmane RS. Tantravedi S, et al. Among authors: hosmane rs. Bioorg Med Chem. 2013 Sep 1;21(17):4893-903. doi: 10.1016/j.bmc.2013.06.069. Epub 2013 Jul 11. Bioorg Med Chem. 2013. PMID: 23891230 Free PMC article.

7

Synthesis, anticancer activity, and SAR analyses of compounds containing the 5:7-fused 4,6,8-triaminoimidazo[4,5-e][1,3]diazepine ring system.

Xie M, Lapidus RG, Sadowska M, Edelman MJ, Hosmane RS. Xie M, et al. Among authors: hosmane rs. Bioorg Med Chem. 2016 Jun 15;24(12):2595-602. doi: 10.1016/j.bmc.2016.03.015. Epub 2016 Mar 9. Bioorg Med Chem. 2016. PMID: 27134120

8

Structure-activity relationship studies on anti-HCV activity of ring-expanded ('fat') nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system.

Zhang P, Zhang N, Korba BE, Hosmane RS. Zhang P, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2225-8. doi: 10.1016/j.bmcl.2007.01.085. Epub 2007 Feb 2. Bioorg Med Chem Lett. 2007. PMID: 17300935 Free PMC article.

9

Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5:7-fused imidazo[4,5-e][1,3]diazepine ring system. In vitro results and implications.

Zhang N, Zhang P, Baier A, Cova L, Hosmane RS. Zhang N, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1154-7. doi: 10.1016/j.bmcl.2013.12.121. Epub 2014 Jan 8. Bioorg Med Chem Lett. 2014. PMID: 24461293 Free PMC article.

10

Chemical and biological effects of substitution of the 2-position of ring-expanded ('fat') nucleosides containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system: the role of electronic and steric factors on glycosidic bond stability and anti-HCV activity.

Zhang P, Zhang N, Buckwold VE, Hosmane RS. Zhang P, et al. Among authors: hosmane rs. Bioorg Med Chem. 2007 Jul 15;15(14):4933-45. doi: 10.1016/j.bmc.2007.04.043. Epub 2007 Apr 29. Bioorg Med Chem. 2007. PMID: 17507230 Free PMC article.

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