Hosmane RS - Search Results

1

Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring System.

Kondaskar A, Kondaskar S, Kumar R, Fishbein JC, Muvarak N, Lapidus RG, Sadowska M, Edelman MJ, Bol GM, Vesuna F, Raman V, Hosmane RS. Kondaskar A, et al. Among authors: hosmane rs. ACS Med Chem Lett. 2010 Dec 31;2(3):252-256. doi: 10.1021/ml100281b. ACS Med Chem Lett. 2010. PMID: 21572541 Free PMC article.

2

The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical properties.

Kumar R, Ujjinamatada RK, Hosmane RS. Kumar R, et al. Among authors: hosmane rs. Org Lett. 2008 Oct 16;10(20):4681-4. doi: 10.1021/ol8020176. Epub 2008 Sep 25. Org Lett. 2008. PMID: 18816128 Free PMC article.

3

A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system.

Xie M, Ujjinamatada RK, Sadowska M, Lapidus RG, Edelman MJ, Hosmane RS. Xie M, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4386-9. doi: 10.1016/j.bmcl.2010.06.061. Epub 2010 Jun 15. Bioorg Med Chem Lett. 2010. PMID: 20594843 Free PMC article.

4

A novel transition state analog inhibitor of guanase based on azepinomycin ring structure: Synthesis and biochemical assessment of enzyme inhibition.

Chakraborty S, Shah NH, Fishbein JC, Hosmane RS. Chakraborty S, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2011 Jan 15;21(2):756-9. doi: 10.1016/j.bmcl.2010.11.109. Epub 2010 Nov 27. Bioorg Med Chem Lett. 2011. PMID: 21183343 Free PMC article.

5

Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues.

Chakraborty S, Shah NH, Fishbein JC, Hosmane RS. Chakraborty S, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7214-8. doi: 10.1016/j.bmcl.2012.09.053. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084905 Free PMC article.

6

Structure-based drug design and potent anti-cancer activity of tricyclic 5:7:5-fused diimidazo[4,5-d:4',5'-f][1,3]diazepines.

Kondaskar A, Kondaskar S, Fishbein JC, Carter-Cooper BA, Lapidus RG, Sadowska M, Edelman MJ, Hosmane RS. Kondaskar A, et al. Among authors: hosmane rs. Bioorg Med Chem. 2013 Feb 1;21(3):618-31. doi: 10.1016/j.bmc.2012.11.050. Epub 2012 Dec 11. Bioorg Med Chem. 2013. PMID: 23290252 Free PMC article.

7

Synthesis, anticancer activity, and SAR analyses of compounds containing the 5:7-fused 4,6,8-triaminoimidazo[4,5-e][1,3]diazepine ring system.

Xie M, Lapidus RG, Sadowska M, Edelman MJ, Hosmane RS. Xie M, et al. Among authors: hosmane rs. Bioorg Med Chem. 2016 Jun 15;24(12):2595-602. doi: 10.1016/j.bmc.2016.03.015. Epub 2016 Mar 9. Bioorg Med Chem. 2016. PMID: 27134120

8

Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: synthesis, biochemical screening, and structure-activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepines.

Tantravedi S, Chakraborty S, Shah NH, Fishbein JC, Hosmane RS. Tantravedi S, et al. Among authors: hosmane rs. Bioorg Med Chem. 2013 Sep 1;21(17):4893-903. doi: 10.1016/j.bmc.2013.06.069. Epub 2013 Jul 11. Bioorg Med Chem. 2013. PMID: 23891230 Free PMC article.

9

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3.

Xie M, Vesuna F, Botlagunta M, Bol GM, Irving A, Bergman Y, Hosmane RS, Kato Y, Winnard PT Jr, Raman V. Xie M, et al. Among authors: hosmane rs. Oncotarget. 2015 Oct 6;6(30):29901-13. doi: 10.18632/oncotarget.4898. Oncotarget. 2015. PMID: 26337079 Free PMC article.

10

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

Bol GM, Vesuna F, Xie M, Zeng J, Aziz K, Gandhi N, Levine A, Irving A, Korz D, Tantravedi S, Heerma van Voss MR, Gabrielson K, Bordt EA, Polster BM, Cope L, van der Groep P, Kondaskar A, Rudek MA, Hosmane RS, van der Wall E, van Diest PJ, Tran PT, Raman V. Bol GM, et al. Among authors: hosmane rs. EMBO Mol Med. 2015 May;7(5):648-69. doi: 10.15252/emmm.201404368. EMBO Mol Med. 2015. PMID: 25820276 Free PMC article.

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