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Antibody engineering to improve manufacturability.
Wijesuriya SD, Pongo E, Tomic M, Zhang F, Garcia-Rodriquez C, Conrad F, Farr-Jones S, Marks JD, Horwitz AH. Wijesuriya SD, et al. Among authors: horwitz ah. Protein Expr Purif. 2018 Sep;149:75-83. doi: 10.1016/j.pep.2018.04.003. Epub 2018 Apr 12. Protein Expr Purif. 2018. PMID: 29655788
An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lep(ob) /Lep(ob) mouse.
Bhaskar V, Goldfine ID, Gerstner R, Michelson K, Tran C, Nonet G, Bohmann D, Pongo E, Zhao J, Horwitz AH, Takeuchi T, White M, Corbin JA. Bhaskar V, et al. Among authors: horwitz ah. Obesity (Silver Spring). 2016 Aug;24(8):1687-94. doi: 10.1002/oby.21539. Epub 2016 Jun 21. Obesity (Silver Spring). 2016. PMID: 27330016 Free article.
Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.
Roell MK, Issafras H, Bauer RJ, Michelson KS, Mendoza N, Vanegas SI, Gross LM, Larsen PD, Bedinger DH, Bohmann DJ, Nonet GH, Liu N, Lee SR, Handa M, Kantak SS, Horwitz AH, Hunter JJ, Owyang AM, Mirza AM, Corbin JA, White ML. Roell MK, et al. Among authors: horwitz ah. J Biol Chem. 2010 Jul 2;285(27):20607-14. doi: 10.1074/jbc.M110.115790. Epub 2010 Apr 21. J Biol Chem. 2010. PMID: 20410301 Free PMC article.
Enhancement of antibody fragment secretion into the Escherichia coli periplasm by co-expression with the peptidyl prolyl isomerase, FkpA, in the cytoplasm.
Levy R, Ahluwalia K, Bohmann DJ, Giang HM, Schwimmer LJ, Issafras H, Reddy NB, Chan C, Horwitz AH, Takeuchi T. Levy R, et al. Among authors: horwitz ah. J Immunol Methods. 2013 Aug 30;394(1-2):10-21. doi: 10.1016/j.jim.2013.04.010. Epub 2013 Apr 23. J Immunol Methods. 2013. PMID: 23624043 Free article.
38 results