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Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
Mol Cancer. 2022 Feb 4;21(1):35. doi: 10.1186/s12943-022-01496-x.
Mol Cancer. 2022.
PMID: 35120522
Free PMC article.
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Fernández-Pisonero I, Clavaín L, Robles-Valero J, Lorenzo-Martín LF, Caloto R, Nieto B, García-Macías C, Oeste CL, Sánchez-Martín M, Abad A, Hortal A, Caballero D, González M, Dosil M, Alarcón B, Bustelo XR.
Fernández-Pisonero I, et al.
Cell Rep. 2022 Mar 15;38(11):110522. doi: 10.1016/j.celrep.2022.110522.
Cell Rep. 2022.
PMID: 35294890
Free article.
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An Optimized Single Nucleotide Polymorphism-Based Detection Method Suggests That Allelic Variants in the 3' Untranslated Region of RRAS2 Correlate with Treatment Response in Chronic Lymphocytic Leukemia Patients.
Hortal A, Lacuna M, Cifuentes C, Alcoceba M, Bustelo XR, González M, Alarcón B.
Hortal A, et al.
Cancers (Basel). 2023 Jan 19;15(3):644. doi: 10.3390/cancers15030644.
Cancers (Basel). 2023.
PMID: 36765602
Free PMC article.
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Characterization of Three Somatic Mutations in the 3'UTR of RRAS2 and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia.
Lacuna M, Hortal AM, Cifuentes C, Gonzalo T, Alcoceba M, Bastos M, Bustelo XR, González M, Alarcón B.
Lacuna M, et al. Among authors: hortal am.
Cells. 2023 Nov 22;12(23):2687. doi: 10.3390/cells12232687.
Cells. 2023.
PMID: 38067115
Free PMC article.
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Oncogenic role of cytomegalovirus in medulloblastoma?
Hortal AM, Vermeulen JF, Van Hecke W, Bovenschen N.
Hortal AM, et al.
Cancer Lett. 2017 Nov 1;408:55-59. doi: 10.1016/j.canlet.2017.08.024. Epub 2017 Aug 24.
Cancer Lett. 2017.
PMID: 28844716
Free article.
Review.
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Two novel variants of the ABCG5 gene cause xanthelasmas and macrothrombocytopenia: a brief review of hematologic abnormalities of sitosterolemia.
Bastida JM, Benito R, Janusz K, Díez-Campelo M, Hernández-Sánchez JM, Marcellini S, Girós M, Rivera J, Lozano ML, Hortal A, Hernández-Rivas JM, González-Porras JR.
Bastida JM, et al.
J Thromb Haemost. 2017 Sep;15(9):1859-1866. doi: 10.1111/jth.13777. Epub 2017 Aug 5.
J Thromb Haemost. 2017.
PMID: 28696550
Free article.
Review.
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Mice Overexpressing Wild-Type RRAS2 Are a Novel Model for Preclinical Testing of Anti-Chronic Lymphocytic Leukemia Therapies.
Hortal AM, Villanueva A, Arellano I, Prieto C, Mendoza P, Bustelo XR, Alarcón B.
Hortal AM, et al.
Cancers (Basel). 2023 Dec 12;15(24):5817. doi: 10.3390/cancers15245817.
Cancers (Basel). 2023.
PMID: 38136362
Free PMC article.
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