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Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
Hortal AM, Oeste CL, Cifuentes C, Alcoceba M, Fernández-Pisonero I, Clavaín L, Tercero R, Mendoza P, Domínguez V, García-Flores M, Pintado B, Abia D, García-Macías C, Navarro-Bailón A, Bustelo XR, González M, Alarcón B. Hortal AM, et al. Mol Cancer. 2022 Feb 4;21(1):35. doi: 10.1186/s12943-022-01496-x. Mol Cancer. 2022. PMID: 35120522 Free PMC article.
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
Fernández-Pisonero I, Clavaín L, Robles-Valero J, Lorenzo-Martín LF, Caloto R, Nieto B, García-Macías C, Oeste CL, Sánchez-Martín M, Abad A, Hortal A, Caballero D, González M, Dosil M, Alarcón B, Bustelo XR. Fernández-Pisonero I, et al. Cell Rep. 2022 Mar 15;38(11):110522. doi: 10.1016/j.celrep.2022.110522. Cell Rep. 2022. PMID: 35294890 Free article.
Oncogenic role of cytomegalovirus in medulloblastoma?
Hortal AM, Vermeulen JF, Van Hecke W, Bovenschen N. Hortal AM, et al. Cancer Lett. 2017 Nov 1;408:55-59. doi: 10.1016/j.canlet.2017.08.024. Epub 2017 Aug 24. Cancer Lett. 2017. PMID: 28844716 Free article. Review.
Two novel variants of the ABCG5 gene cause xanthelasmas and macrothrombocytopenia: a brief review of hematologic abnormalities of sitosterolemia.
Bastida JM, Benito R, Janusz K, Díez-Campelo M, Hernández-Sánchez JM, Marcellini S, Girós M, Rivera J, Lozano ML, Hortal A, Hernández-Rivas JM, González-Porras JR. Bastida JM, et al. J Thromb Haemost. 2017 Sep;15(9):1859-1866. doi: 10.1111/jth.13777. Epub 2017 Aug 5. J Thromb Haemost. 2017. PMID: 28696550 Free article. Review.