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Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike SI, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N. Nishimura T, et al. Among authors: horike si. Oncogene. 2019 Apr;38(14):2464-2481. doi: 10.1038/s41388-018-0589-1. Epub 2018 Dec 7. Oncogene. 2019. PMID: 30532069 Free PMC article.
Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy.
Sheng J, Kohno S, Okada N, Okahashi N, Teranishi K, Matsuda F, Shimizu H, Linn P, Nagatani N, Yamamura M, Harada K, Horike SI, Inoue H, Yano S, Kumar S, Kitajima S, Ajioka I, Takahashi C. Sheng J, et al. Among authors: horike si. Hepatology. 2021 Oct;74(4):1971-1993. doi: 10.1002/hep.31872. Epub 2021 Aug 25. Hepatology. 2021. PMID: 33931882
FOXP4 inhibits squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3-dependent pathway.
Matsumoto T, Iizuka T, Nakamura M, Suzuki T, Yamamoto M, Ono M, Kagami K, Kasama H, Wakae K, Muramatsu M, Horike SI, Kyo S, Yamamoto Y, Mizumoto Y, Daikoku T, Fujiwara H. Matsumoto T, et al. Among authors: horike si. Cancer Sci. 2022 Oct;113(10):3376-3389. doi: 10.1111/cas.15489. Epub 2022 Aug 1. Cancer Sci. 2022. PMID: 35838233 Free PMC article.
A maternal high-fat diet induces fetal origins of NASH-HCC in mice.
Takiyama T, Sera T, Nakamura M, Hoshino M, Uesugi K, Horike SI, Meguro-Horike M, Bessho R, Takiyama Y, Kitsunai H, Takeda Y, Sawamoto K, Yagi N, Nishikawa Y, Takiyama Y. Takiyama T, et al. Among authors: horike si. Sci Rep. 2022 Jul 30;12(1):13136. doi: 10.1038/s41598-022-17501-8. Sci Rep. 2022. PMID: 35907977 Free PMC article.
The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice.
Inaba Y, Hashiuchi E, Watanabe H, Kimura K, Oshima Y, Tsuchiya K, Murai S, Takahashi C, Matsumoto M, Kitajima S, Yamamoto Y, Honda M, Asahara SI, Ravnskjaer K, Horike SI, Kaneko S, Kasuga M, Nakano H, Harada K, Inoue H. Inaba Y, et al. Among authors: horike si. Nat Commun. 2023 Jan 23;14(1):167. doi: 10.1038/s41467-023-35804-w. Nat Commun. 2023. PMID: 36690638 Free PMC article.
Potential therapeutic target secretogranin II might cooperate with hypoxia-inducible factor 1α in sunitinib-resistant renal cell carcinoma.
Fukumoto W, Yoshino H, Horike SI, Kawakami I, Tamai M, Arima J, Kawahara I, Mitsuke A, Sakaguchi T, Inoguchi S, Meguro-Horike M, Tatarano S, Enokida H. Fukumoto W, et al. Among authors: horike si. Cancer Sci. 2023 Oct;114(10):3946-3956. doi: 10.1111/cas.15914. Epub 2023 Aug 6. Cancer Sci. 2023. PMID: 37545017 Free PMC article.
Aging-associated impairment in metabolic compensation by subcutaneous adipose tissue promotes diet-induced fatty liver disease in mice.
Taketani H, Nishikawa T, Nakajima H, Kodo K, Sugimoto S, Aoi W, Horike SI, Meguro-Horike M, Ishiba H, Seko Y, Umemura A, Yamaguchi K, Moriguchi M, Yasui K, Itoh Y. Taketani H, et al. Among authors: horike si. Diabetes Metab Syndr Obes. 2019 Aug 23;12:1473-1492. doi: 10.2147/DMSO.S214093. eCollection 2019. Diabetes Metab Syndr Obes. 2019. PMID: 31692556 Free PMC article.
69 results