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Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Kohara T, Nakayama K, Watanabe K, Kusaka SI, Sakai D, Tanaka H, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Mori A, Tanaka S, Bessho T, Takiguchi-Hayashi K, Horikawa T. Kohara T, et al. Among authors: horikawa t. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3733-3738. doi: 10.1016/j.bmcl.2017.06.077. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712706
2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors.
Fukunaga K, Uehara F, Aritomo K, Shoda A, Hiki S, Okuyama M, Usui Y, Watanabe K, Yamakoshi K, Kohara T, Hanano T, Tanaka H, Tsuchiya S, Sunada S, Saito K, Eguchi J, Yuki S, Asano S, Tanaka S, Mori A, Yamagami K, Baba H, Horikawa T, Fujimura M. Fukunaga K, et al. Among authors: horikawa t. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7. doi: 10.1016/j.bmcl.2013.09.020. Epub 2013 Sep 21. Bioorg Med Chem Lett. 2013. PMID: 24176395
Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease.
Fukunaga K, Sakai D, Watanabe K, Nakayama K, Kohara T, Tanaka H, Sunada S, Nabeno M, Okamoto M, Saito K, Eguchi J, Mori A, Tanaka S, Inazawa K, Horikawa T. Fukunaga K, et al. Among authors: horikawa t. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1086-91. doi: 10.1016/j.bmcl.2015.01.005. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25655721
Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Usui Y, Uehara F, Hiki S, Watanabe K, Tanaka H, Shouda A, Yokoshima S, Aritomo K, Adachi T, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Yamagami K, Asano S, Tanaka S, Yuki S, Yoshii N, Fujimura M, Horikawa T. Usui Y, et al. Among authors: horikawa t. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3726-3732. doi: 10.1016/j.bmcl.2017.06.078. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712708
(R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties.
Tatsumi R, Fujio M, Takanashi S, Numata A, Katayama J, Satoh H, Shiigi Y, Maeda J, Kuriyama M, Horikawa T, Murozono T, Hashimoto K, Tanaka H. Tatsumi R, et al. Among authors: horikawa t. J Med Chem. 2006 Jul 13;49(14):4374-83. doi: 10.1021/jm060249c. J Med Chem. 2006. PMID: 16821797
Inhibition of mitogen-activated protein kinase kinase, DNA methyltransferase, and transforming growth factor-β promotes differentiation of human induced pluripotent stem cells into enterocytes.
Kodama N, Iwao T, Kabeya T, Horikawa T, Niwa T, Kondo Y, Nakamura K, Matsunaga T. Kodama N, et al. Among authors: horikawa t. Drug Metab Pharmacokinet. 2016 Jun;31(3):193-200. doi: 10.1016/j.dmpk.2016.02.002. Epub 2016 Feb 17. Drug Metab Pharmacokinet. 2016. PMID: 27161454
Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in age-related infertility.
Ito M, Muraki M, Takahashi Y, Imai M, Tsukui T, Yamakawa N, Nakagawa K, Ohgi S, Horikawa T, Iwasaki W, Iida A, Nishi Y, Yanase T, Nawata H, Miyado K, Kono T, Hosoi Y, Saito H. Ito M, et al. Among authors: horikawa t. Fertil Steril. 2008 Oct;90(4):1026-35. doi: 10.1016/j.fertnstert.2007.07.1389. Epub 2007 Oct 24. Fertil Steril. 2008. PMID: 17919612 Free article.
334 results