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Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Capano LS, Sato C, Ficulle E, Yu A, Horie K, Kwon JS, Burbach KF, Barthélemy NR, Fox SG, Karch CM, Bateman RJ, Houlden H, Morimoto RI, Holtzman DM, Duff KE, Yoo AS. Capano LS, et al. Among authors: horie k. Cell Stem Cell. 2022 Jun 2;29(6):918-932.e8. doi: 10.1016/j.stem.2022.04.018. Cell Stem Cell. 2022. PMID: 35659876 Free PMC article.
Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction.
Ezerskiy LA, Schoch KM, Sato C, Beltcheva M, Horie K, Rigo F, Martynowicz R, Karch CM, Bateman RJ, Miller TM. Ezerskiy LA, et al. Among authors: horie k. JCI Insight. 2022 Jan 11;7(1):e152012. doi: 10.1172/jci.insight.152012. JCI Insight. 2022. PMID: 34874917 Free PMC article.
CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease.
Strain JF, Barthelemy N, Horie K, Gordon BA, Kilgore C, Aschenbrenner A, Cruchaga C, Xiong C, Joseph-Mathurin N, Hassenstab J, Fagan AM, Li Y, Karch CM, Perrin RJ, Berman SB, Chhatwal JP, Graff-Radford NR, Mori H, Levin J, Noble JM, Allegri R, Schofield PR, Marcus DS, Holtzman DM, Morris JC, Benzinger TLS, McDade EM, Bateman RJ, Ances BM. Strain JF, et al. Among authors: horie k. Neurobiol Dis. 2022 Jun 15;168:105714. doi: 10.1016/j.nbd.2022.105714. Epub 2022 Mar 28. Neurobiol Dis. 2022. PMID: 35358703 Free PMC article.
Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease.
Roberts M, Sevastou I, Imaizumi Y, Mistry K, Talma S, Dey M, Gartlon J, Ochiai H, Zhou Z, Akasofu S, Tokuhara N, Ogo M, Aoyama M, Aoyagi H, Strand K, Sajedi E, Agarwala KL, Spidel J, Albone E, Horie K, Staddon JM, de Silva R. Roberts M, et al. Among authors: horie k. Acta Neuropathol Commun. 2020 Feb 4;8(1):13. doi: 10.1186/s40478-020-0884-2. Acta Neuropathol Commun. 2020. PMID: 32019610 Free PMC article.
758 results