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Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.
Gorecki L, Misiachna A, Damborsky J, Dolezal R, Korabecny J, Cejkova L, Hakenova K, Chvojkova M, Karasova JZ, Prchal L, Novak M, Kolcheva M, Kortus S, Vales K, Horak M, Soukup O. Gorecki L, et al. Among authors: horak m. Eur J Med Chem. 2021 Jul 5;219:113434. doi: 10.1016/j.ejmech.2021.113434. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33892271 Free article.
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.
Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E, Fedunova D, Horak M, Kaniakova M, Wang ZJ, Hamouda AK, Kuca K. Gazova Z, et al. Among authors: horak m. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):607-619. doi: 10.1016/j.bbadis.2016.11.020. Epub 2016 Nov 16. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27865910 Free article.
The pharmacology of tacrine at N-methyl-d-aspartate receptors.
Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A, Ricny J, Vales K, Soukup O. Horak M, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:54-62. doi: 10.1016/j.pnpbp.2017.01.003. Epub 2017 Jan 13. Prog Neuropsychopharmacol Biol Psychiatry. 2017. PMID: 28089695 Review.
7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo.
Kaniakova M, Kleteckova L, Lichnerova K, Holubova K, Skrenkova K, Korinek M, Krusek J, Smejkalova T, Korabecny J, Vales K, Soukup O, Horak M. Kaniakova M, et al. Among authors: horak m. Neuropharmacology. 2018 Sep 15;140:217-232. doi: 10.1016/j.neuropharm.2018.08.010. Epub 2018 Aug 9. Neuropharmacology. 2018. PMID: 30099049
175 results