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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13.
Nat Chem. 2022.
PMID: 34903857
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW.
Mousnier A, et al. Among authors: hopkins navratilova i.
Nat Chem. 2018 Jun;10(6):599-606. doi: 10.1038/s41557-018-0039-2. Epub 2018 May 14.
Nat Chem. 2018.
PMID: 29760414
Free PMC article.
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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.
Henderson SH, Sorrell F, Bennett J, Fedorov O, Hanley MT, Godoi PH, Ruela de Sousa R, Robinson S, Ashall-Kelly A, Hopkins Navratilova I, Walter DS, Elkins JM, Ward SE.
Henderson SH, et al. Among authors: hopkins navratilova i.
J Med Chem. 2021 Aug 12;64(15):11709-11728. doi: 10.1021/acs.jmedchem.1c01115. Epub 2021 Aug 3.
J Med Chem. 2021.
PMID: 34342227
Free PMC article.
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Mining Public Domain Data to Develop Selective DYRK1A Inhibitors.
Henderson SH, Sorrell F, Bennett J, Hanley MT, Robinson S, Hopkins Navratilova I, Elkins JM, Ward SE.
Henderson SH, et al. Among authors: hopkins navratilova i.
ACS Med Chem Lett. 2020 Jun 30;11(8):1620-1626. doi: 10.1021/acsmedchemlett.0c00279. eCollection 2020 Aug 13.
ACS Med Chem Lett. 2020.
PMID: 32832032
Free PMC article.
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A mutant O-GlcNAcase enriches Drosophila developmental regulators.
Selvan N, Williamson R, Mariappa D, Campbell DG, Gourlay R, Ferenbach AT, Aristotelous T, Hopkins-Navratilova I, Trost M, van Aalten DMF.
Selvan N, et al. Among authors: hopkins navratilova i.
Nat Chem Biol. 2017 Aug;13(8):882-887. doi: 10.1038/nchembio.2404. Epub 2017 Jun 12.
Nat Chem Biol. 2017.
PMID: 28604694
Free PMC article.
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