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Progress towards a public chemogenomic set for protein kinases and a call for contributions.
Drewry DH, Wells CI, Andrews DM, Angell R, Al-Ali H, Axtman AD, Capuzzi SJ, Elkins JM, Ettmayer P, Frederiksen M, Gileadi O, Gray N, Hooper A, Knapp S, Laufer S, Luecking U, Michaelides M, Müller S, Muratov E, Denny RA, Saikatendu KS, Treiber DK, Zuercher WJ, Willson TM. Drewry DH, et al. Among authors: hooper a. PLoS One. 2017 Aug 2;12(8):e0181585. doi: 10.1371/journal.pone.0181585. eCollection 2017. PLoS One. 2017. PMID: 28767711 Free PMC article.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: hooper a. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.
Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro).
Han SH, Goins CM, Arya T, Shin WJ, Maw J, Hooper A, Sonawane DP, Porter MR, Bannister BE, Crouch RD, Lindsey AA, Lakatos G, Martinez SR, Alvarado J, Akers WS, Wang NS, Jung JU, Macdonald JD, Stauffer SR. Han SH, et al. Among authors: hooper a. J Med Chem. 2022 Feb 24;65(4):2880-2904. doi: 10.1021/acs.jmedchem.1c00598. Epub 2021 Aug 4. J Med Chem. 2022. PMID: 34347470 Free PMC article.
Fracturing and tectonic stress drive ultrarapid magma flow into dikes.
Sigmundsson F, Parks M, Geirsson H, Hooper A, Drouin V, Vogfjörd KS, Ófeigsson BG, Greiner SHM, Yang Y, Lanzi C, De Pascale GP, Jónsdóttir K, Hreinsdóttir S, Tolpekin V, Friðriksdóttir HM, Einarsson P, Barsotti S. Sigmundsson F, et al. Among authors: hooper a. Science. 2024 Mar 15;383(6688):1228-1235. doi: 10.1126/science.adn2838. Epub 2024 Feb 8. Science. 2024. PMID: 38330140
Potential of muvalaplin as a lipoprotein(a) inhibitor.
Hooper AJ, Fernando PMS, Burnett JR. Hooper AJ, et al. Expert Opin Investig Drugs. 2024 Jan;33(1):5-7. doi: 10.1080/13543784.2024.2302592. Epub 2024 Feb 12. Expert Opin Investig Drugs. 2024. PMID: 38186354 No abstract available.
520 results