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Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor.
Bioorg Med Chem Lett. 2016 Dec 15;26(24):5977-5984. doi: 10.1016/j.bmcl.2016.10.079. Epub 2016 Nov 1.
Bioorg Med Chem Lett. 2016.
PMID: 27865703
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model.
Muthukaman N, Tambe M, Shaikh M, Pisal D, Deshmukh S, Tondlekar S, Sarode N, Narayana L, Gajera JM, Kattige VG, Honnegowda S, Karande V, Kulkarni A, Behera D, Jadhav SB, Gudi GS, Khairatkar-Joshi N, Gharat LA.
Muthukaman N, et al. Among authors: honnegowda s.
Bioorg Med Chem Lett. 2017 Jun 1;27(11):2594-2601. doi: 10.1016/j.bmcl.2017.03.068. Epub 2017 Mar 24.
Bioorg Med Chem Lett. 2017.
PMID: 28400234
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Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1.
Muthukaman N, Tambe M, Deshmukh S, Pisal D, Tondlekar S, Shaikh M, Sarode N, Kattige VG, Pisat M, Sawant P, Honnegowda S, Karande V, Kulkarni A, Behera D, Jadhav SB, Sangana RR, Gudi GS, Khairatkar-Joshi N, Gharat LA.
Muthukaman N, et al. Among authors: honnegowda s.
Bioorg Med Chem Lett. 2017 Dec 1;27(23):5131-5138. doi: 10.1016/j.bmcl.2017.10.062.
Bioorg Med Chem Lett. 2017.
PMID: 29100801
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Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2.
Muthukaman N, Deshmukh S, Tambe M, Pisal D, Tondlekar S, Shaikh M, Sarode N, Kattige VG, Sawant P, Pisat M, Karande V, Honnegowda S, Kulkarni A, Behera D, Jadhav SB, Sangana RR, Gudi GS, Khairatkar-Joshi N, Gharat LA.
Muthukaman N, et al. Among authors: honnegowda s.
Bioorg Med Chem Lett. 2018 Apr 15;28(7):1211-1218. doi: 10.1016/j.bmcl.2018.02.048. Epub 2018 Feb 28.
Bioorg Med Chem Lett. 2018.
PMID: 29519738
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Embelin ameliorates dextran sodium sulfate-induced colitis in mice.
Kumar G K, Dhamotharan R, Kulkarni NM, Honnegowda S, Murugesan S.
Kumar G K, et al. Among authors: honnegowda s.
Int Immunopharmacol. 2011 Jun;11(6):724-31. doi: 10.1016/j.intimp.2011.01.022. Epub 2011 Feb 3.
Int Immunopharmacol. 2011.
PMID: 21296695
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The use of a neonatal mouse model to study respiratory syncytial virus infections.
Cormier SA, You D, Honnegowda S.
Cormier SA, et al. Among authors: honnegowda s.
Expert Rev Anti Infect Ther. 2010 Dec;8(12):1371-80. doi: 10.1586/eri.10.125.
Expert Rev Anti Infect Ther. 2010.
PMID: 21133663
Free PMC article.
Review.
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Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease.
Ripple MJ, You D, Honnegowda S, Giaimo JD, Sewell AB, Becnel DM, Cormier SA.
Ripple MJ, et al. Among authors: honnegowda s.
J Immunol. 2010 Oct 15;185(8):4804-11. doi: 10.4049/jimmunol.1000484. Epub 2010 Sep 22.
J Immunol. 2010.
PMID: 20861354
Free PMC article.
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