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Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling.
Stadler S, Nguyen CH, Schachner H, Milovanovic D, Holzner S, Brenner S, Eichsteininger J, Stadler M, Senfter D, Krenn L, Schmidt WM, Huttary N, Krieger S, Koperek O, Bago-Horvath Z, Brendel KA, Marian B, de Wever O, Mader RM, Giessrigl B, Jäger W, Dolznig H, Krupitza G. Stadler S, et al. Among authors: holzner s. Cell Mol Life Sci. 2017 May;74(10):1907-1921. doi: 10.1007/s00018-016-2441-5. Epub 2016 Dec 24. Cell Mol Life Sci. 2017. PMID: 28013338 Free PMC article.
Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro.
Holzner S, Brenner S, Atanasov AG, Senfter D, Stadler S, Nguyen CH, Fristiohady A, Milovanovic D, Huttary N, Krieger S, Bago-Horvath Z, de Wever O, Tentes I, Özmen A, Jäger W, Dolznig H, Dirsch VM, Mader RM, Krenn L, Krupitza G. Holzner S, et al. Food Chem Toxicol. 2018 Jan;111:114-124. doi: 10.1016/j.fct.2017.11.015. Epub 2017 Nov 10. Food Chem Toxicol. 2018. PMID: 29129665
12(S)-HETE increases intracellular Ca(2+) in lymph-endothelial cells disrupting their barrier function in vitro; stabilization by clinical drugs impairing calcium supply.
Nguyen CH, Brenner S, Huttary N, Li Y, Atanasov AG, Dirsch VM, Holzner S, Stadler S, Riha J, Krieger S, Milovanovic D, Fristiohardy A, Simonitsch-Klupp I, Dolznig H, Saiko P, Szekeres T, Giessrigl B, Jäger W, Krupitza G. Nguyen CH, et al. Among authors: holzner s. Cancer Lett. 2016 Sep 28;380(1):174-83. doi: 10.1016/j.canlet.2016.06.022. Epub 2016 Jul 4. Cancer Lett. 2016. PMID: 27390016
Inhibition of p38/MK2 Signaling Prevents Vascular Invasion of Melanoma.
Wenzina J, Holzner S, Puujalka E, Cheng PF, Forsthuber A, Neumüller K, Schossleitner K, Lichtenberger BM, Levesque MP, Petzelbauer P. Wenzina J, et al. Among authors: holzner s. J Invest Dermatol. 2020 Apr;140(4):878-890.e5. doi: 10.1016/j.jid.2019.08.451. Epub 2019 Oct 14. J Invest Dermatol. 2020. PMID: 31622599 Free article.
NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro.
Nguyen CH, Senfter D, Basilio J, Holzner S, Stadler S, Krieger S, Huttary N, Milovanovic D, Viola K, Simonitsch-Klupp I, Jäger W, de Martin R, Krupitza G. Nguyen CH, et al. Among authors: holzner s. Oncotarget. 2015 Nov 17;6(36):39262-75. doi: 10.18632/oncotarget.5741. Oncotarget. 2015. PMID: 26513020 Free PMC article.
Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model.
Nguyen CH, Huttary N, Atanasov AG, Chatuphonprasert W, Brenner S, Fristiohady A, Hong J, Stadler S, Holzner S, Milovanovic D, Dirsch VM, Kopp B, Saiko P, Krenn L, Jäger W, Krupitza G. Nguyen CH, et al. Among authors: holzner s. Int J Oncol. 2017 May;50(5):1879-1888. doi: 10.3892/ijo.2017.3956. Epub 2017 Apr 7. Int J Oncol. 2017. PMID: 28393180
A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro.
Blaschke M, McKinnon R, Nguyen CH, Holzner S, Zehl M, Atanasov AG, Schelch K, Krieger S, Diaz R, Frisch R, Feistel B, Jäger W, Ecker GF, Dirsch VM, Grusch M, Zupko I, Urban E, Kopp B, Krupitza G. Blaschke M, et al. Among authors: holzner s. Mutat Res. 2015 Jul;777:79-90. doi: 10.1016/j.mrfmmm.2015.04.011. Epub 2015 May 5. Mutat Res. 2015. PMID: 25989051
49 results