Holz GG - Search Results

1

Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways.

Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Basile G, et al. Among authors: holz gg. Cell Metab. 2023 Jul 11;35(7):1242-1260.e9. doi: 10.1016/j.cmet.2023.05.007. Epub 2023 Jun 19. Cell Metab. 2023. PMID: 37339634 Free PMC article.

2

Corrination mitigates peptide aggregation as exemplified for Glucagon.

Liles A, Cham N, Opp ML, Tinsley IC, Chepurny OG, Holz GG, Doyle RP. Liles A, et al. Among authors: holz gg. Peptides. 2024 Jan;171:171134. doi: 10.1016/j.peptides.2023.171134. Epub 2023 Dec 12. Peptides. 2024. PMID: 38092266

3

GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Lepr^db/db mice.

Meng Q, Tian X, Li J, Pruekprasert N, Dhawan R, Holz GG, Cooney RN. Meng Q, et al. Among authors: holz gg. Sci Rep. 2022 Dec 26;12(1):22360. doi: 10.1038/s41598-022-27015-y. Sci Rep. 2022. PMID: 36572735 Free PMC article.

4

A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss.

Chichura KS, Elfers CT, Salameh TS, Kamat V, Chepurny OG, McGivney A, Milliken BT, Holz GG, Applebey SV, Hayes MR, Sweet IR, Roth CL, Doyle RP. Chichura KS, et al. Among authors: holz gg. Sci Rep. 2023 Jun 12;13(1):9554. doi: 10.1038/s41598-023-36178-1. Sci Rep. 2023. PMID: 37308546 Free PMC article.

5

Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK₂R Cancer Theranostic Agents: A Preclinical Study.

Nock BA, Kanellopoulos P, Chepurny OG, Rouchota M, Loudos G, Holz GG, Krenning EP, Maina T. Nock BA, et al. Among authors: holz gg. Pharmaceutics. 2022 Mar 18;14(3):666. doi: 10.3390/pharmaceutics14030666. Pharmaceutics. 2022. PMID: 35336041 Free PMC article.

6

The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice.

Meng Q, Chepurny OG, Leech CA, Pruekprasert N, Molnar ME, Collier JJ, Cooney RN, Holz GG. Meng Q, et al. Among authors: holz gg. Diabetes Obes Metab. 2022 Jul;24(7):1255-1266. doi: 10.1111/dom.14693. Epub 2022 Apr 7. Diabetes Obes Metab. 2022. PMID: 35293666 Free PMC article.

7

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.

Cabrera O, Ficorilli J, Shaw J, Echeverri F, Schwede F, Chepurny OG, Leech CA, Holz GG. Cabrera O, et al. Among authors: holz gg. J Biol Chem. 2022 Feb;298(2):101484. doi: 10.1016/j.jbc.2021.101484. Epub 2021 Dec 9. J Biol Chem. 2022. PMID: 34896391 Free PMC article.

8

Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists.

Elgiushy HR, Abou-Taleb NA, Holz GG, Chepurny OG, Pirmettis I, Kakabakos S, Karageorgos V, Liapakis G, Albohy A, Abouzid KAM, Hammad SF. Elgiushy HR, et al. Among authors: holz gg. Bioorg Chem. 2021 Sep;114:105079. doi: 10.1016/j.bioorg.2021.105079. Epub 2021 Jun 10. Bioorg Chem. 2021. PMID: 34174633 Free PMC article.

9

Cyclic AMP-dependent activation of ERK via GLP-1 receptor signalling requires the neuroendocrine cell-specific guanine nucleotide exchanger NCS-RapGEF2.

Xu W, Dahlke SP, Emery AC, Sung M, Chepurny OG, Holz GG, Eiden LE. Xu W, et al. Among authors: holz gg. J Neuroendocrinol. 2021 May 6;33(7):e12974. doi: 10.1111/jne.12974. Online ahead of print. J Neuroendocrinol. 2021. PMID: 33960038 Free PMC article.

10

Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4.

Tinsley IC, Borner T, Swanson ML, Chepurny OG, Doebley SA, Kamat V, Sweet IR, Holz GG, Hayes MR, De Jonghe BC, Doyle RP. Tinsley IC, et al. Among authors: holz gg. J Med Chem. 2021 Mar 25;64(6):3479-3492. doi: 10.1021/acs.jmedchem.1c00185. Epub 2021 Mar 6. J Med Chem. 2021. PMID: 33677970 Free PMC article.

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