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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Bell RD, et al. Among authors: holtzman dm. Nature. 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087. Nature. 2012. PMID: 22622580 Free PMC article.
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. Cirrito JR, et al. Among authors: holtzman dm. J Clin Invest. 2005 Nov;115(11):3285-90. doi: 10.1172/JCI25247. Epub 2005 Oct 20. J Clin Invest. 2005. PMID: 16239972 Free PMC article.
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Castellano JM, et al. Among authors: holtzman dm. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15502-7. doi: 10.1073/pnas.1206446109. Epub 2012 Aug 27. Proc Natl Acad Sci U S A. 2012. PMID: 22927427 Free PMC article.
Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice.
Han BH, Zhou ML, Johnson AW, Singh I, Liao F, Vellimana AK, Nelson JW, Milner E, Cirrito JR, Basak J, Yoo M, Dietrich HH, Holtzman DM, Zipfel GJ. Han BH, et al. Among authors: holtzman dm. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E881-90. doi: 10.1073/pnas.1414930112. Epub 2015 Feb 9. Proc Natl Acad Sci U S A. 2015. PMID: 25675483 Free PMC article.
695 results