Holthuis JCM - Search Results

1

Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase.

Jahn H, Bartoš L, Dearden GI, Dittman JS, Holthuis JCM, Vácha R, Menon AK. Jahn H, et al. Among authors: holthuis jcm. Nat Commun. 2023 Dec 8;14(1):8115. doi: 10.1038/s41467-023-43570-y. Nat Commun. 2023. PMID: 38065946 Free PMC article.

2

Lipid landscapes and pipelines in membrane homeostasis.

Holthuis JC, Menon AK. Holthuis JC, et al. Nature. 2014 Jun 5;510(7503):48-57. doi: 10.1038/nature13474. Nature. 2014. PMID: 24899304 Review.

3

An alliance between lipid transfer proteins and scramblases for membrane expansion.

Holthuis JCM, Jahn H, Menon AK, Mizushima N. Holthuis JCM, et al. Fac Rev. 2022 Aug 16;11:22. doi: 10.12703/r-01-0000015. eCollection 2022. Fac Rev. 2022. PMID: 36081427 Free PMC article.

4

Ceramides bind VDAC2 to trigger mitochondrial apoptosis.

Dadsena S, Bockelmann S, Mina JGM, Hassan DG, Korneev S, Razzera G, Jahn H, Niekamp P, Müller D, Schneider M, Tafesse FG, Marrink SJ, Melo MN, Holthuis JCM. Dadsena S, et al. Among authors: holthuis jcm. Nat Commun. 2019 Apr 23;10(1):1832. doi: 10.1038/s41467-019-09654-4. Nat Commun. 2019. PMID: 31015432 Free PMC article.

5

Ca²⁺-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair.

Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, Südhoff E, Hilderink A, Imlau M, Clarke CJ, Hensel M, Burd CG, Holthuis JCM. Niekamp P, et al. Among authors: holthuis jcm. Nat Commun. 2022 Apr 6;13(1):1875. doi: 10.1038/s41467-022-29481-4. Nat Commun. 2022. PMID: 35388011 Free PMC article.

6

Unraveling the molecular principles by which ceramides commit cells to death.

Dadsena S, Hassan DG, Holthuis JCM. Dadsena S, et al. Among authors: holthuis jcm. Cell Stress. 2019 Jul 16;3(8):280-283. doi: 10.15698/cst2019.08.196. Cell Stress. 2019. PMID: 31440742 Free PMC article.

7

A switchable ceramide transfer protein for dissecting the mechanism of ceramide-induced mitochondrial apoptosis.

Jain A, Dadsena S, Holthuis JCM. Jain A, et al. Among authors: holthuis jcm. FEBS Lett. 2020 Nov;594(22):3739-3750. doi: 10.1002/1873-3468.13956. Epub 2020 Oct 26. FEBS Lett. 2020. PMID: 33058150 Free article.

8

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis.

Jain A, Beutel O, Ebell K, Korneev S, Holthuis JC. Jain A, et al. J Cell Sci. 2017 Jan 15;130(2):360-371. doi: 10.1242/jcs.194191. Epub 2016 Nov 25. J Cell Sci. 2017. PMID: 27888218

9

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain.

Cabukusta B, Kol M, Kneller L, Hilderink A, Bickert A, Mina JG, Korneev S, Holthuis JC. Cabukusta B, et al. Sci Rep. 2017 Jan 25;7:41290. doi: 10.1038/srep41290. Sci Rep. 2017. PMID: 28120887 Free PMC article.

10

Membrane damage and repair: a thin line between life and death.

Barisch C, Holthuis JCM, Cosentino K. Barisch C, et al. Among authors: holthuis jcm. Biol Chem. 2023 Feb 23;404(5):467-490. doi: 10.1515/hsz-2022-0321. Print 2023 Apr 25. Biol Chem. 2023. PMID: 36810295 Free article. Review.

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