Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue.
Nordberg J, Zhong L, Holmgren A, Arnér ES.
Nordberg J, et al. Among authors: holmgren a.
J Biol Chem. 1998 May 1;273(18):10835-42. doi: 10.1074/jbc.273.18.10835.
J Biol Chem. 1998.
PMID: 9556556
Free article.
The immunostimulatory dinitrohalobenzene compound 1-chloro-2, 4-dinitrobenzene (DNCB) irreversibly inhibits mammalian thioredoxin reductase (TrxR) in the presence of NADPH, inducing an NADPH oxidase activity in the modified enzyme (Arner, E. S. J., Bjornstedt, M., and Holmgren …
The immunostimulatory dinitrohalobenzene compound 1-chloro-2, 4-dinitrobenzene (DNCB) irreversibly inhibits mammalian thioredoxin reductase …