Hollfelder F - Search Results

1

Functional metagenomic screening identifies an unexpected β-glucuronidase.

Neun S, Brear P, Campbell E, Tryfona T, El Omari K, Wagner A, Dupree P, Hyvönen M, Hollfelder F. Neun S, et al. Among authors: hollfelder f. Nat Chem Biol. 2022 Oct;18(10):1096-1103. doi: 10.1038/s41589-022-01071-x. Epub 2022 Jul 7. Nat Chem Biol. 2022. PMID: 35799064

2

A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum.

Jonas S, van Loo B, Hyvönen M, Hollfelder F. Jonas S, et al. Among authors: hollfelder f. J Mol Biol. 2008 Dec 5;384(1):120-36. doi: 10.1016/j.jmb.2008.08.072. Epub 2008 Sep 4. J Mol Biol. 2008. PMID: 18793651

3

An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily.

van Loo B, Jonas S, Babtie AC, Benjdia A, Berteau O, Hyvönen M, Hollfelder F. van Loo B, et al. Among authors: hollfelder f. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2740-5. doi: 10.1073/pnas.0903951107. Epub 2010 Jan 27. Proc Natl Acad Sci U S A. 2010. PMID: 20133613 Free PMC article.

4

Reverse evolution leads to genotypic incompatibility despite functional and active site convergence.

Kaltenbach M, Jackson CJ, Campbell EC, Hollfelder F, Tokuriki N. Kaltenbach M, et al. Among authors: hollfelder f. Elife. 2015 Aug 14;4:e06492. doi: 10.7554/eLife.06492. Elife. 2015. PMID: 26274563 Free PMC article.

5

Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.

Colin PY, Kintses B, Gielen F, Miton CM, Fischer G, Mohamed MF, Hyvönen M, Morgavi DP, Janssen DB, Hollfelder F. Colin PY, et al. Among authors: hollfelder f. Nat Commun. 2015 Dec 7;6:10008. doi: 10.1038/ncomms10008. Nat Commun. 2015. PMID: 26639611 Free PMC article.

6

The role of protein dynamics in the evolution of new enzyme function.

Campbell E, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M, Hollfelder F, Tokuriki N, Jackson CJ. Campbell E, et al. Among authors: hollfelder f. Nat Chem Biol. 2016 Nov;12(11):944-950. doi: 10.1038/nchembio.2175. Epub 2016 Sep 12. Nat Chem Biol. 2016. PMID: 27618189

7

Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.

van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, Hyvönen M, Hollfelder F. van Loo B, et al. Among authors: hollfelder f. J Mol Biol. 2018 Mar 30;430(7):1004-1023. doi: 10.1016/j.jmb.2018.02.010. Epub 2018 Feb 17. J Mol Biol. 2018. PMID: 29458126 Free PMC article.

8

Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.

Miton CM, Jonas S, Fischer G, Duarte F, Mohamed MF, van Loo B, Kintses B, Kamerlin SCL, Tokuriki N, Hyvönen M, Hollfelder F. Miton CM, et al. Among authors: hollfelder f. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7293-E7302. doi: 10.1073/pnas.1607817115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012610 Free PMC article.

9

Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.

van Loo B, Bayer CD, Fischer G, Jonas S, Valkov E, Mohamed MF, Vorobieva A, Dutruel C, Hyvönen M, Hollfelder F. van Loo B, et al. Among authors: hollfelder f. J Am Chem Soc. 2019 Jan 9;141(1):370-387. doi: 10.1021/jacs.8b10290. Epub 2018 Dec 20. J Am Chem Soc. 2019. PMID: 30497259

10

Single-cell activity screening in microfluidic droplets.

Neun S, Kaminski TS, Hollfelder F. Neun S, et al. Among authors: hollfelder f. Methods Enzymol. 2019;628:95-112. doi: 10.1016/bs.mie.2019.07.009. Epub 2019 Aug 8. Methods Enzymol. 2019. PMID: 31668237

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