Holien JK - Search Results

1

Functional interaction between compound heterozygous TERT mutations causes severe telomere biology disorder.

Niaz A, Truong J, Manoleras A, Fox LC, Blombery P, Vasireddy RS, Pickett HA, Curtin JA, Barbaro PM, Rodgers J, Roy J, Riley LG, Holien JK, Cohen SB, Bryan TM. Niaz A, et al. Among authors: holien jk. Blood Adv. 2022 Jun 28;6(12):3779-3791. doi: 10.1182/bloodadvances.2022007029. Blood Adv. 2022. PMID: 35477117 Free PMC article.

2

Direct involvement of the TEN domain at the active site of human telomerase.

Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM. Jurczyluk J, et al. Among authors: holien jk. Nucleic Acids Res. 2011 Mar;39(5):1774-88. doi: 10.1093/nar/gkq1083. Epub 2010 Nov 3. Nucleic Acids Res. 2011. PMID: 21051362 Free PMC article.

3

Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.

Tomlinson CG, Moye AL, Holien JK, Parker MW, Cohen SB, Bryan TM. Tomlinson CG, et al. Among authors: holien jk. Biochem J. 2015 Jan 15;465(2):347-57. doi: 10.1042/BJ20140922. Biochem J. 2015. PMID: 25365545

4

The C-terminal extension of human telomerase reverse transcriptase is necessary for high affinity binding to telomeric DNA.

Tomlinson CG, Holien JK, Mathias JA, Parker MW, Bryan TM. Tomlinson CG, et al. Among authors: holien jk. Biochimie. 2016 Sep-Oct;128-129:114-21. doi: 10.1016/j.biochi.2016.07.010. Epub 2016 Jul 22. Biochimie. 2016. PMID: 27456246 Free article.

5

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution.

Paudel BP, Moye AL, Abou Assi H, El-Khoury R, Cohen SB, Holien JK, Birrento ML, Samosorn S, Intharapichai K, Tomlinson CG, Teulade-Fichou MP, González C, Beck JL, Damha MJ, van Oijen AM, Bryan TM. Paudel BP, et al. Among authors: holien jk. Elife. 2020 Jul 29;9:e56428. doi: 10.7554/eLife.56428. Elife. 2020. PMID: 32723475 Free PMC article.

6

Analysis of physicochemical properties of protein-protein interaction modulators suggests stronger alignment with the "rule of five".

Truong J, George A, Holien JK. Truong J, et al. Among authors: holien jk. RSC Med Chem. 2021 Jul 27;12(10):1731-1749. doi: 10.1039/d1md00213a. eCollection 2021 Oct 20. RSC Med Chem. 2021. PMID: 34778774 Free PMC article.

7

A novel small molecule inhibitor of human Drp1.

Rosdah AA, Abbott BM, Langendorf CG, Deng Y, Truong JQ, Waddell HMM, Ling NXY, Smiles WJ, Delbridge LMD, Liu GS, Oakhill JS, Lim SY, Holien JK. Rosdah AA, et al. Among authors: holien jk. Sci Rep. 2022 Dec 13;12(1):21531. doi: 10.1038/s41598-022-25464-z. Sci Rep. 2022. PMID: 36513726 Free PMC article.

8

Zanamivir-resistant influenza viruses with a novel neuraminidase mutation.

Hurt AC, Holien JK, Parker M, Kelso A, Barr IG. Hurt AC, et al. Among authors: holien jk. J Virol. 2009 Oct;83(20):10366-73. doi: 10.1128/JVI.01200-09. Epub 2009 Jul 29. J Virol. 2009. PMID: 19641000 Free PMC article.

9

Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses.

Hurt AC, Holien JK, Parker MW, Barr IG. Hurt AC, et al. Among authors: holien jk. Drugs. 2009;69(18):2523-31. doi: 10.2165/11531450-000000000-00000. Drugs. 2009. PMID: 19943705

10

Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V.

Quesada-Soriano I, Parker LJ, Primavera A, Wielens J, Holien JK, Casas-Solvas JM, Vargas-Berenguel A, Aguilera AM, Nuccetelli M, Mazzetti AP, Lo Bello M, Parker MW, García-Fuentes L. Quesada-Soriano I, et al. Among authors: holien jk. J Mol Recognit. 2011 Mar-Apr;24(2):220-34. doi: 10.1002/jmr.1040. J Mol Recognit. 2011. PMID: 20540076

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