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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.
J Immunother Cancer. 2023 Jun;11(6):e006728. doi: 10.1136/jitc-2023-006728.
J Immunother Cancer. 2023.
PMID: 37344101
Free PMC article.
The complex biology of aryl hydrocarbon receptor activation in cancer and beyond.
Opitz CA, Holfelder P, Prentzell MT, Trump S.
Opitz CA, et al. Among authors: holfelder p.
Biochem Pharmacol. 2023 Oct;216:115798. doi: 10.1016/j.bcp.2023.115798. Epub 2023 Sep 9.
Biochem Pharmacol. 2023.
PMID: 37696456
Free PMC article.
Review.
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