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Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.
Elife. 2020 Apr 14;9:e54695. doi: 10.7554/eLife.54695.
Elife. 2020.
PMID: 32286228
Free PMC article.
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss.
Yu W, Zhong L, Yao L, Wei Y, Gui T, Li Z, Kim H, Holdreith N, Jiang X, Tong W, Dyment N, Liu XS, Yang S, Choi Y, Ahn J, Qin L.
Yu W, et al. Among authors: holdreith n.
J Clin Invest. 2021 Jan 19;131(2):e140214. doi: 10.1172/JCI140214.
J Clin Invest. 2021.
PMID: 33206630
Free PMC article.
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Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
Zhong L, Yao L, Holdreith N, Yu W, Gui T, Miao Z, Elkaim Y, Li M, Gong Y, Pacifici M, Maity A, Busch TM, Joeng KS, Cengel K, Seale P, Tong W, Qin L.
Zhong L, et al. Among authors: holdreith n.
JCI Insight. 2022 Apr 8;7(7):e150323. doi: 10.1172/jci.insight.150323.
JCI Insight. 2022.
PMID: 35393948
Free PMC article.
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LNK (SH2B3) inhibition expands healthy and Fanconi anemia human hematopoietic stem and progenitor cells.
Holdreith N, Lee G, Chandra V, Salinas CS, Nicholas P, Olson TS, Tong W.
Holdreith N, et al.
Blood Adv. 2022 Feb 8;6(3):731-745. doi: 10.1182/bloodadvances.2021004205.
Blood Adv. 2022.
PMID: 34844262
Free PMC article.
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Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Balcerek J, Jiang J, Li Y, Jiang Q, Holdreith N, Singh B, Chandra V, Lv K, Ren JG, Rozenova K, Li W, Greenberg RA, Tong W.
Balcerek J, et al. Among authors: holdreith n.
Nat Commun. 2018 Sep 25;9(1):3915. doi: 10.1038/s41467-018-06380-1.
Nat Commun. 2018.
PMID: 30254368
Free PMC article.
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RUNX-1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells.
Estevez B, Borst S, Jarocha D, Sudunagunta V, Gonzalez M, Garifallou J, Hakonarson H, Gao P, Tan K, Liu P, Bagga S, Holdreith N, Tong W, Speck N, French DL, Gadue P, Poncz M.
Estevez B, et al. Among authors: holdreith n.
Blood. 2021 May 13;137(19):2662-2675. doi: 10.1182/blood.2020006389.
Blood. 2021.
PMID: 33569577
Free PMC article.
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Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone.
Zhong L, Lu J, Fang J, Yao L, Yu W, Gui T, Duffy M, Holdreith N, Bautista CA, Huang X, Bandyopadhyay S, Tan K, Chen C, Choi Y, Jiang JX, Yang S, Tong W, Dyment N, Qin L.
Zhong L, et al. Among authors: holdreith n.
Elife. 2023 Feb 13;12:e82112. doi: 10.7554/eLife.82112.
Elife. 2023.
PMID: 36779854
Free PMC article.
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Annexin A2 links poor myofiber repair with inflammation and adipogenic replacement of the injured muscle.
Defour A, Medikayala S, Van der Meulen JH, Hogarth MW, Holdreith N, Malatras A, Duddy W, Boehler J, Nagaraju K, Jaiswal JK.
Defour A, et al. Among authors: holdreith n.
Hum Mol Genet. 2017 Jun 1;26(11):1979-1991. doi: 10.1093/hmg/ddx065.
Hum Mol Genet. 2017.
PMID: 28334824
Free PMC article.
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