Holdfeldt A - Search Results

1

The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics.

Skovbakke SL, Holdfeldt A, Forsman H, Bylund J, Franzyk H. Skovbakke SL, et al. Among authors: holdfeldt a. Curr Pharm Des. 2018;24(10):1100-1120. doi: 10.2174/1381612824666180403123233. Curr Pharm Des. 2018. PMID: 29611477 Review.

2

The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2 Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase.

Holdfeldt A, Skovbakke SL, Winther M, Gabl M, Nielsen C, Perez-Gassol I, Larsen CJ, Wang JM, Karlsson A, Dahlgren C, Forsman H, Franzyk H. Holdfeldt A, et al. J Biol Chem. 2016 Sep 16;291(38):19888-99. doi: 10.1074/jbc.M116.736850. Epub 2016 Jul 15. J Biol Chem. 2016. PMID: 27422818 Free PMC article.

3

The peptidomimetic Lau-(Lys-βNSpe)₆-NH₂ antagonizes formyl peptide receptor 2 expressed in mouse neutrophils.

Skovbakke SL, Winther M, Gabl M, Holdfeldt A, Linden S, Wang JM, Dahlgren C, Franzyk H, Forsman H. Skovbakke SL, et al. Among authors: holdfeldt a. Biochem Pharmacol. 2016 Nov 1;119:56-65. doi: 10.1016/j.bcp.2016.09.004. Epub 2016 Sep 8. Biochem Pharmacol. 2016. PMID: 27614010

4

Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists.

Skovbakke SL, Holdfeldt A, Nielsen C, Hansen AM, Perez-Gassol I, Dahlgren C, Forsman H, Franzyk H. Skovbakke SL, et al. Among authors: holdfeldt a. J Med Chem. 2017 Aug 24;60(16):6991-6997. doi: 10.1021/acs.jmedchem.7b00489. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28700225

5

Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor Activation.

Viklund M, Fredriksson J, Holdfeldt A, Lind S, Franzyk H, Dahlgren C, Sundqvist M, Forsman H. Viklund M, et al. Among authors: holdfeldt a. J Immunol. 2022 Apr 1;208(7):1632-1641. doi: 10.4049/jimmunol.2101039. Epub 2022 Mar 23. J Immunol. 2022. PMID: 35321878

6

A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk mechanism.

Gabl M, Holdfeldt A, Winther M, Oprea T, Bylund J, Dahlgren C, Forsman H. Gabl M, et al. Among authors: holdfeldt a. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1228-37. doi: 10.1016/j.bbamcr.2016.03.014. Epub 2016 Mar 18. Biochim Biophys Acta. 2016. PMID: 26996596 Free article.

7

Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria.

Dahlgren C, Gabl M, Holdfeldt A, Winther M, Forsman H. Dahlgren C, et al. Among authors: holdfeldt a. Biochem Pharmacol. 2016 Aug 15;114:22-39. doi: 10.1016/j.bcp.2016.04.014. Epub 2016 Apr 27. Biochem Pharmacol. 2016. PMID: 27131862 Review.

8

Formylated MHC Class Ib Binding Peptides Activate Both Human and Mouse Neutrophils Primarily through Formyl Peptide Receptor 1.

Winther M, Holdfeldt A, Gabl M, Wang JM, Forsman H, Dahlgren C. Winther M, et al. Among authors: holdfeldt a. PLoS One. 2016 Dec 1;11(12):e0167529. doi: 10.1371/journal.pone.0167529. eCollection 2016. PLoS One. 2016. PMID: 27907124 Free PMC article.

9

Reactivation of Gαi-coupled formyl peptide receptors is inhibited by Gαq-selective inhibitors when induced by signals generated by the platelet-activating factor receptor.

Holdfeldt A, Dahlstrand Rudin A, Gabl M, Rajabkhani Z, König GM, Kostenis E, Dahlgren C, Forsman H. Holdfeldt A, et al. J Leukoc Biol. 2017 Sep;102(3):871-880. doi: 10.1189/jlb.2A0317-086RR. Epub 2017 Jul 31. J Leukoc Biol. 2017. PMID: 28760822

10

Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question.

Winther M, Holdfeldt A, Sundqvist M, Rajabkhani Z, Gabl M, Bylund J, Dahlgren C, Forsman H. Winther M, et al. Among authors: holdfeldt a. PLoS One. 2017 Sep 21;12(9):e0185132. doi: 10.1371/journal.pone.0185132. eCollection 2017. PLoS One. 2017. PMID: 28934373 Free PMC article.

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