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Imaging synaptic density in the living human brain.
Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Finnema SJ, et al. Among authors: holden d. Sci Transl Med. 2016 Jul 20;8(348):348ra96. doi: 10.1126/scitranslmed.aaf6667. Sci Transl Med. 2016. PMID: 27440727 Clinical Trial.
PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates.
Hillmer AT, Zheng MQ, Li S, Scheunemann M, Lin SF, Holden D, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Carson RE, Brust P, Huang Y. Hillmer AT, et al. Among authors: holden d. Eur J Nucl Med Mol Imaging. 2016 Mar;43(3):537-47. doi: 10.1007/s00259-015-3209-0. Epub 2015 Oct 12. Eur J Nucl Med Mol Imaging. 2016. PMID: 26455500 Free PMC article.
Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action.
Nicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H. Nicolas JM, et al. Among authors: holden d. Epilepsia. 2016 Feb;57(2):201-9. doi: 10.1111/epi.13267. Epub 2015 Dec 10. Epilepsia. 2016. PMID: 26663401 Free article.
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain.
Nabulsi NB, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y. Nabulsi NB, et al. Among authors: holden d. J Nucl Med. 2016 May;57(5):777-84. doi: 10.2967/jnumed.115.168179. Epub 2016 Feb 4. J Nucl Med. 2016. PMID: 26848175 Free article.
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging.
Han L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. Han L, et al. Among authors: holden d. ACS Nano. 2016 Apr 26;10(4):4209-18. doi: 10.1021/acsnano.5b07573. Epub 2016 Mar 16. ACS Nano. 2016. PMID: 26967254 Free PMC article.
453 results