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Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants.
Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, Boyd LF, Nguyen H, Pomerenke A, Stephens T, Olia AS, Zhang B, De Giorgi V, Holbrook MR, Gross R, Postnikova E, Garza NL, Johnson RF, Margulies DH, Kwong PD, Alter HJ, Buchholz UJ, Lusso P, Farci P. Chen Z, et al. Among authors: holbrook mr. Cell Rep. 2022 Nov 1;41(5):111528. doi: 10.1016/j.celrep.2022.111528. Epub 2022 Sep 30. Cell Rep. 2022. PMID: 36302375 Free PMC article.
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Dacon C, Peng L, Lin TH, Tucker C, Lee CD, Cong Y, Wang L, Purser L, Cooper AJR, Williams JK, Pyo CW, Yuan M, Kosik I, Hu Z, Zhao M, Mohan D, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Murphy M, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Doranz BJ, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Mascola JR, Holbrook MR, Nemazee D, Wilson IA, Tan J. Dacon C, et al. Among authors: holbrook mr. Cell Host Microbe. 2023 Jan 11;31(1):97-111.e12. doi: 10.1016/j.chom.2022.10.010. Epub 2022 Nov 7. Cell Host Microbe. 2023. PMID: 36347257 Free PMC article.
Evaluation of a panel of therapeutic antibody clinical candidates for efficacy against SARS-CoV-2 in Syrian hamsters.
Cong Y, Mucker EM, Perry DL, Dixit S, Kollins E, Byrum R, Huzella L, Kim R, Josleyn M, Kwilas S, Stefan C, Shoemaker CJ, Koehler J, Coyne S, Delp K, Liang J, Drawbaugh D, Hischak A, Hart R, Postnikova E, Vaughan N, Asher J, St Claire M, Hanson J, Schmaljohn C, Eakin AE, Hooper JW, Holbrook MR. Cong Y, et al. Among authors: holbrook mr. Antiviral Res. 2023 May;213:105589. doi: 10.1016/j.antiviral.2023.105589. Epub 2023 Mar 30. Antiviral Res. 2023. PMID: 37003305 Free PMC article.
Longitudinal analyses using 18F-Fluorodeoxyglucose positron emission tomography with computed tomography as a measure of COVID-19 severity in the aged, young, and humanized ACE2 SARS-CoV-2 hamster models.
Cong Y, Lee JH, Perry DL, Cooper K, Wang H, Dixit S, Liu DX, Feuerstein IM, Solomon J, Bartos C, Seidel J, Hammoud DA, Adams R, Anthony SM, Liang J, Schuko N, Li R, Liu Y, Wang Z, Tarbet EB, Hischak AMW, Hart R, Isic N, Burdette T, Drawbaugh D, Huzella LM, Byrum R, Ragland D, St Claire MC, Wada J, Kurtz JR, Hensley LE, Schmaljohn CS, Holbrook MR, Johnson RF. Cong Y, et al. Among authors: holbrook mr. Antiviral Res. 2023 Jun;214:105605. doi: 10.1016/j.antiviral.2023.105605. Epub 2023 Apr 15. Antiviral Res. 2023. PMID: 37068595 Free PMC article.
Clinical and Immunologic Correlates of Vasodilatory Shock Among Ebola Virus-Infected Nonhuman Primates in a Critical Care Model.
Stein SR, Platt AP, Teague HL, Anthony SM, Reeder RJ, Cooper K, Byrum R, Drawbaugh DJ 2nd, Liu DX, Burdette TL, Hadley K, Barr B, Warner S, Rodriguez-Hernandez F, Johnson C, Stanek P, Hischak J, Kendall H, Huzella LM, Strich JR, Herbert R, St Claire M, Vannella KM, Holbrook MR, Chertow DS. Stein SR, et al. Among authors: holbrook mr. J Infect Dis. 2023 Nov 13;228(Suppl 7):S635-S647. doi: 10.1093/infdis/jiad374. J Infect Dis. 2023. PMID: 37652048 Free PMC article.
Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease.
Liu DX, Pahar B, Perry DL, Xu H, Cooper TK, Huzella LM, Hart RJ, Hischak AMW, Bernbaum J, St Claire M, Byrum R, Bennett RS, Warren T, Holbrook MR, Hensley LE, Crozier I, Schmaljohn CS. Liu DX, et al. Among authors: holbrook mr. Am J Pathol. 2023 Dec;193(12):2031-2046. doi: 10.1016/j.ajpath.2023.08.010. Epub 2023 Sep 7. Am J Pathol. 2023. PMID: 37689386 Free article.
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Dacon C, Peng L, Lin TH, Tucker C, Lee CD, Cong Y, Wang L, Purser L, Cooper AJR, Williams JK, Pyo CW, Yuan M, Kosik I, Hu Z, Zhao M, Mohan D, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Murphy M, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Doranz BJ, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Mascola JR, Holbrook MR, Nemazee D, Wilson IA, Tan J. Dacon C, et al. Among authors: holbrook mr. Cell Host Microbe. 2023 Jun 14;31(6):1071-1072. doi: 10.1016/j.chom.2023.05.016. Cell Host Microbe. 2023. PMID: 37321165 Free PMC article. No abstract available.
142 results