Holan G - Search Results

1

Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention.

McCarthy TD, Karellas P, Henderson SA, Giannis M, O'Keefe DF, Heery G, Paull JR, Matthews BR, Holan G. McCarthy TD, et al. Among authors: holan g. Mol Pharm. 2005 Jul-Aug;2(4):312-8. doi: 10.1021/mp050023q. Mol Pharm. 2005. PMID: 16053334 Review.

2

Evaluation of dendrimer SPL7013, a lead microbicide candidate against herpes simplex viruses.

Gong E, Matthews B, McCarthy T, Chu J, Holan G, Raff J, Sacks S. Gong E, et al. Among authors: holan g. Antiviral Res. 2005 Dec;68(3):139-46. doi: 10.1016/j.antiviral.2005.08.004. Epub 2005 Sep 27. Antiviral Res. 2005. PMID: 16219368

3

Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes.

Bernstein DI, Stanberry LR, Sacks S, Ayisi NK, Gong YH, Ireland J, Mumper RJ, Holan G, Matthews B, McCarthy T, Bourne N. Bernstein DI, et al. Among authors: holan g. Antimicrob Agents Chemother. 2003 Dec;47(12):3784-8. doi: 10.1128/AAC.47.12.3784-3788.2003. Antimicrob Agents Chemother. 2003. PMID: 14638483 Free PMC article.

4

Dendrimers, a new class of candidate topical microbicides with activity against herpes simplex virus infection.

Bourne N, Stanberry LR, Kern ER, Holan G, Matthews B, Bernstein DI. Bourne N, et al. Among authors: holan g. Antimicrob Agents Chemother. 2000 Sep;44(9):2471-4. doi: 10.1128/AAC.44.9.2471-2474.2000. Antimicrob Agents Chemother. 2000. PMID: 10952597 Free PMC article.

5

Evidence of dual sites of action of dendrimers: SPL-2999 inhibits both virus entry and late stages of herpes simplex virus replication.

Gong Y, Matthews B, Cheung D, Tam T, Gadawski I, Leung D, Holan G, Raff J, Sacks S. Gong Y, et al. Among authors: holan g. Antiviral Res. 2002 Aug;55(2):319-29. doi: 10.1016/s0166-3542(02)00054-2. Antiviral Res. 2002. PMID: 12103432

6

Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.

Hantson A, Fikkert V, Van Remoortel B, Pannecouque C, Cherepanov P, Matthews B, Holan G, De Clercq E, Vandamme AM, Debyser Z, Witvrouw M. Hantson A, et al. Among authors: holan g. Antivir Chem Chemother. 2005;16(4):253-66. doi: 10.1177/095632020501600405. Antivir Chem Chemother. 2005. PMID: 16130523 Free article.

7

Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.

Witvrouw M, Fikkert V, Pluymers W, Matthews B, Mardel K, Schols D, Raff J, Debyser Z, De Clercq E, Holan G, Pannecouque C. Witvrouw M, et al. Among authors: holan g. Mol Pharmacol. 2000 Nov;58(5):1100-8. Mol Pharmacol. 2000. PMID: 11040059

8

The use of a scanning proton microprobe to observe anti-HIV drugs within cells.

Cholewa M, Legge GJ, Weigold H, Holan G, Birch CJ. Cholewa M, et al. Among authors: holan g. Life Sci. 1994;54(21):1607-12. doi: 10.1016/0024-3205(94)90032-9. Life Sci. 1994. PMID: 8196479

9

Use of a flavivirus RNA-dependent RNA polymerase assay to investigate the antiviral activity of selected compounds.

Bartholomeusz A, Tomlinson E, Wright PJ, Birch C, Locarnini S, Weigold H, Marcuccio S, Holan G. Bartholomeusz A, et al. Among authors: holan g. Antiviral Res. 1994 Aug;24(4):341-50. doi: 10.1016/0166-3542(94)90080-9. Antiviral Res. 1994. PMID: 7993077

10

Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.

Witvrouw M, Weigold H, Pannecouque C, Schols D, De Clercq E, Holan G. Witvrouw M, et al. Among authors: holan g. J Med Chem. 2000 Mar 9;43(5):778-83. doi: 10.1021/jm980263s. J Med Chem. 2000. PMID: 10715146

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