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Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior.
Bijata M, Bączyńska E, Müller FE, Bijata K, Masternak J, Krzystyniak A, Szewczyk B, Siwiec M, Antoniuk S, Roszkowska M, Figiel I, Magnowska M, Olszyński KH, Wardak AD, Hogendorf A, Ruszczycki B, Gorinski N, Labus J, Stępień T, Tarka S, Bojarski AJ, Tokarski K, Filipkowski RK, Ponimaskin E, Wlodarczyk J. Bijata M, et al. Among authors: hogendorf a. Cell Rep. 2022 Mar 15;38(11):110532. doi: 10.1016/j.celrep.2022.110532. Cell Rep. 2022. PMID: 35294881 Free article.
Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands.
Staroń J, Mordalski S, Warszycki D, Satała G, Hogendorf A, Bojarski AJ. Staroń J, et al. Among authors: hogendorf a. ACS Med Chem Lett. 2017 Mar 27;8(4):390-394. doi: 10.1021/acsmedchemlett.6b00482. eCollection 2017 Apr 13. ACS Med Chem Lett. 2017. PMID: 28435524 Free PMC article.
Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol.
Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bojarski AJ. Hogendorf AS, et al. Among authors: hogendorf a. Sci Rep. 2017 May 4;7(1):1444. doi: 10.1038/s41598-017-00822-4. Sci Rep. 2017. PMID: 28473721 Free PMC article.
Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists.
Latacz G, Hogendorf AS, Hogendorf A, Lubelska A, Wierońska JM, Woźniak M, Cieślik P, Kieć-Kononowicz K, Handzlik J, Bojarski AJ. Latacz G, et al. Among authors: hogendorf as, hogendorf a. Medchemcomm. 2018 Sep 25;9(11):1882-1890. doi: 10.1039/c8md00313k. eCollection 2018 Nov 1. Medchemcomm. 2018. PMID: 30568756 Free PMC article.
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers.
Hogendorf AS, Hogendorf A, Popiołek-Barczyk K, Ciechanowska A, Mika J, Satała G, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Ponimaskin E, Schade S, Zeug A, Bijata M, Kubicki M, Kurczab R, Lenda T, Staroń J, Bugno R, Duszyńska B, Pilarski B, Bojarski AJ. Hogendorf AS, et al. Among authors: hogendorf a. Eur J Med Chem. 2019 May 15;170:261-275. doi: 10.1016/j.ejmech.2019.03.017. Epub 2019 Mar 11. Eur J Med Chem. 2019. PMID: 30904783
Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties.
Staroń J, Kurczab R, Warszycki D, Satała G, Krawczyk M, Bugno R, Lenda T, Popik P, Hogendorf AS, Hogendorf A, Dubiel K, Matłoka M, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Zajdel P, Bojarski AJ. Staroń J, et al. Among authors: hogendorf as, hogendorf a. Eur J Med Chem. 2020 Jan 1;185:111857. doi: 10.1016/j.ejmech.2019.111857. Epub 2019 Nov 7. Eur J Med Chem. 2020. PMID: 31734022 Free article.
Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode.
Staroń J, Bugno R, Pietruś W, Satała G, Mordalski S, Warszycki D, Hogendorf A, Hogendorf AS, Kalinowska-Tłuścik J, Lenda T, Pilarski B, Bojarski AJ. Staroń J, et al. Among authors: hogendorf a, hogendorf as. Eur J Med Chem. 2021 Jan 1;209:112916. doi: 10.1016/j.ejmech.2020.112916. Epub 2020 Oct 9. Eur J Med Chem. 2021. PMID: 33328102
How can fluorine directly and indirectly affect the hydrogen bonding in molecular systems? - A case study for monofluoroanilines.
Pietruś W, Kurczab R, Kafel R, Machalska E, Kalinowska-Tłuścik J, Hogendorf A, Żylewski M, Baranska M, Bojarski AJ. Pietruś W, et al. Among authors: hogendorf a. Spectrochim Acta A Mol Biomol Spectrosc. 2021 May 5;252:119536. doi: 10.1016/j.saa.2021.119536. Epub 2021 Feb 3. Spectrochim Acta A Mol Biomol Spectrosc. 2021. PMID: 33588362
Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands - Fluoxetine and fluvoxamine.
Staroń J, Pietruś W, Bugno R, Kurczab R, Satała G, Warszycki D, Lenda T, Wantuch A, Hogendorf AS, Hogendorf A, Duszyńska B, Bojarski AJ. Staroń J, et al. Among authors: hogendorf as, hogendorf a. Eur J Med Chem. 2021 Aug 5;220:113533. doi: 10.1016/j.ejmech.2021.113533. Epub 2021 May 14. Eur J Med Chem. 2021. PMID: 34049262
43 results