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Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors.
Potenza M, Giordano A, Chini MG, Saviano A, Kretzer C, Raucci F, Russo M, Lauro G, Terracciano S, Bruno I, Iorizzi M, Hofstetter RK, Pace S, Maione F, Werz O, Bifulco G. Potenza M, et al. Among authors: hofstetter rk. ACS Med Chem Lett. 2022 Dec 9;14(1):26-34. doi: 10.1021/acsmedchemlett.2c00343. eCollection 2023 Jan 12. ACS Med Chem Lett. 2022. PMID: 36655121 Free PMC article.
Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators.
Pace S, Zhang K, Jordan PM, Bilancia R, Wang W, Börner F, Hofstetter RK, Potenza M, Kretzer C, Gerstmeier J, Fischer D, Lorkowski S, Gilbert NC, Newcomer ME, Rossi A, Chen X, Werz O. Pace S, et al. Among authors: hofstetter rk. Pharmacol Res. 2021 May;167:105556. doi: 10.1016/j.phrs.2021.105556. Epub 2021 Mar 31. Pharmacol Res. 2021. PMID: 33812006
Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design.
Friedrich L, Cingolani G, Ko YH, Iaselli M, Miciaccia M, Perrone MG, Neukirch K, Bobinger V, Merk D, Hofstetter RK, Werz O, Koeberle A, Scilimati A, Schneider G. Friedrich L, et al. Among authors: hofstetter rk. Adv Sci (Weinh). 2021 Aug;8(16):e2100832. doi: 10.1002/advs.202100832. Epub 2021 Jun 27. Adv Sci (Weinh). 2021. PMID: 34176236 Free PMC article.
Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways.
Potenza M, Sciarretta M, Chini MG, Saviano A, Maione F, D'Auria MV, De Marino S, Giordano A, Hofstetter RK, Festa C, Werz O, Bifulco G. Potenza M, et al. Among authors: hofstetter rk. Eur J Med Chem. 2021 Nov 15;224:113693. doi: 10.1016/j.ejmech.2021.113693. Epub 2021 Jul 13. Eur J Med Chem. 2021. PMID: 34315041
Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages.
Kretzer C, Jordan PM, Meyer KPL, Hoff D, Werner M, Hofstetter RK, Koeberle A, Cala Peralta A, Viault G, Seraphin D, Richomme P, Helesbeux JJ, Stuppner H, Temml V, Schuster D, Werz O. Kretzer C, et al. Among authors: hofstetter rk. Biochem Pharmacol. 2022 Jan;195:114825. doi: 10.1016/j.bcp.2021.114825. Epub 2021 Nov 8. Biochem Pharmacol. 2022. PMID: 34762841
In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway.
Saviano A, De Vita S, Chini MG, Marigliano N, Lauro G, Casillo GM, Raucci F, Iorizzi M, Hofstetter RK, Fischer K, Koeberle A, Werz O, Maione F, Bifulco G. Saviano A, et al. Among authors: hofstetter rk. Biomolecules. 2022 Jan 7;12(1):99. doi: 10.3390/biom12010099. Biomolecules. 2022. PMID: 35053247 Free PMC article.
21 results