Hofman FM - Search Results

1

Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs.

Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. Schönthal AH, et al. Among authors: hofman fm. Expert Opin Investig Drugs. 2008 Feb;17(2):197-208. doi: 10.1517/13543784.17.2.197. Expert Opin Investig Drugs. 2008. PMID: 18230053 Review.

2

Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.

Kardosh A, Wang W, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. Cancer Biol Ther. 2005 May;4(5):571-82. doi: 10.4161/cbt.4.5.1699. Epub 2005 May 5. Cancer Biol Ther. 2005. PMID: 15846081

3

Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib.

Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. Blood. 2005 Dec 15;106(13):4330-8. doi: 10.1182/blood-2005-07-2819. Epub 2005 Aug 25. Blood. 2005. PMID: 16123214 Free article.

4

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.

Pyrko P, Soriano N, Kardosh A, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen CS, Chen TC, Schönthal AH. Pyrko P, et al. Among authors: hofman fm. Mol Cancer. 2006 May 18;5:19. doi: 10.1186/1476-4598-5-19. Mol Cancer. 2006. PMID: 16707021 Free PMC article.

5

Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib.

Kardosh A, Soriano N, Pyrko P, Liu YT, Jabbour M, Hofman FM, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. J Biomed Sci. 2007 Sep;14(5):647-62. doi: 10.1007/s11373-007-9173-3. Epub 2007 Apr 18. J Biomed Sci. 2007. PMID: 17440835

6

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib.

Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH. Kardosh A, et al. Among authors: hofman fm. Cancer Res. 2008 Feb 1;68(3):843-51. doi: 10.1158/0008-5472.CAN-07-5555. Cancer Res. 2008. PMID: 18245486

7

Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress.

Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH. Cho HY, et al. Among authors: hofman fm. Cancer Lett. 2009 Sep 8;282(1):87-97. doi: 10.1016/j.canlet.2009.03.007. Epub 2009 Apr 3. Cancer Lett. 2009. PMID: 19345476

8

Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature.

Virrey JJ, Liu Z, Cho HY, Kardosh A, Golden EB, Louie SG, Gaffney KJ, Petasis NA, Schönthal AH, Chen TC, Hofman FM. Virrey JJ, et al. Among authors: hofman fm. Mol Cancer Ther. 2010 Mar;9(3):631-41. doi: 10.1158/1535-7163.MCT-09-0652. Epub 2010 Mar 2. Mol Cancer Ther. 2010. PMID: 20197398

9

Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response.

Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. Schönthal AH, et al. Among authors: hofman fm. Curr Pharm Des. 2011;17(23):2428-38. doi: 10.2174/138161211797249242. Curr Pharm Des. 2011. PMID: 21827419 Review.

10

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors.

Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, Petasis NA, Chen TC, Hofman FM, Louie SG, Schönthal AH. Thomas S, et al. Among authors: hofman fm. Cancer Lett. 2012 Dec 1;325(1):63-71. doi: 10.1016/j.canlet.2012.05.030. Epub 2012 Jun 1. Cancer Lett. 2012. PMID: 22664238

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