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LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.
Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, van Bilsen M, Bakker J, Binder CJ, Lütjohann D, Staels B, Hofker MH, Shiri-Sverdlov R. Bieghs V, et al. Among authors: hofker mh. PLoS One. 2012;7(1):e30668. doi: 10.1371/journal.pone.0030668. Epub 2012 Jan 25. PLoS One. 2012. PMID: 22295101 Free PMC article.
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice.
Bieghs V, Hendrikx T, van Gorp PJ, Verheyen F, Guichot YD, Walenbergh SM, Jeurissen ML, Gijbels M, Rensen SS, Bast A, Plat J, Kalhan SC, Koek GH, Leitersdorf E, Hofker MH, Lütjohann D, Shiri-Sverdlov R. Bieghs V, et al. Among authors: hofker mh. Gastroenterology. 2013 Jan;144(1):167-178.e1. doi: 10.1053/j.gastro.2012.09.062. Epub 2012 Oct 3. Gastroenterology. 2013. PMID: 23041327
Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice.
Hendrikx T, Jeurissen ML, Bieghs V, Walenbergh SM, van Gorp PJ, Verheyen F, Houben T, Guichot YD, Gijbels MJ, Leitersdorf E, Hofker MH, Lütjohann D, Shiri-Sverdlov R. Hendrikx T, et al. Among authors: hofker mh. J Hepatol. 2015 Feb;62(2):430-6. doi: 10.1016/j.jhep.2014.09.027. Epub 2014 Oct 2. J Hepatol. 2015. PMID: 25281859
Plasma cathepsin D levels: a novel tool to predict pediatric hepatic inflammation.
Walenbergh SM, Houben T, Hendrikx T, Jeurissen ML, van Gorp PJ, Vreugdenhil AC, Adriaanse MP, Buurman WA, Hofker MH, Mosca A, Lindsey PJ, Alisi A, Liccardo D, Panera N, Koek GH, Nobili V, Shiri-Sverdlov R. Walenbergh SM, et al. Among authors: hofker mh. Am J Gastroenterol. 2015 Mar;110(3):462-70. doi: 10.1038/ajg.2015.29. Epub 2015 Mar 3. Am J Gastroenterol. 2015. PMID: 25732418
Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease.
Hendrikx T, Watzenböck ML, Walenbergh SM, Amir S, Gruber S, Kozma MO, Grabsch HI, Koek GH, Pierik MJ, Staufer K, Trauner M, Kalhan SC, Jonkers D, Hofker MH, Binder CJ, Shiri-Sverdlov R. Hendrikx T, et al. Among authors: hofker mh. BMC Med. 2016 Jul 22;14(1):107. doi: 10.1186/s12916-016-0652-0. BMC Med. 2016. PMID: 27443391 Free PMC article.
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
Walenbergh SM, Houben T, Rensen SS, Bieghs V, Hendrikx T, van Gorp PJ, Oligschlaeger Y, Jeurissen ML, Gijbels MJ, Buurman WA, Vreugdenhil AC, Greve JW, Plat J, Hofker MH, Kalhan S, Pihlajamäki J, Lindsey P, Koek GH, Shiri-Sverdlov R. Walenbergh SM, et al. Among authors: hofker mh. Sci Rep. 2016 Dec 6;6:38278. doi: 10.1038/srep38278. Sci Rep. 2016. PMID: 27922112 Free PMC article.
Cathepsin D regulates lipid metabolism in murine steatohepatitis.
Houben T, Oligschlaeger Y, Hendrikx T, Bitorina AV, Walenbergh SMA, van Gorp PJ, Gijbels MJJ, Friedrichs S, Plat J, Schaap FG, Lütjohann D, Hofker MH, Shiri-Sverdlov R. Houben T, et al. Among authors: hofker mh. Sci Rep. 2017 Jun 14;7(1):3494. doi: 10.1038/s41598-017-03796-5. Sci Rep. 2017. PMID: 28615690 Free PMC article.
265 results