Hoffmann RM - Search Results

1

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents.

Pereira de Sa N, Taouil A, Kim J, Clement T, Hoffmann RM, Burke JE, Rizzo RC, Ojima I, Del Poeta M, Airola MV. Pereira de Sa N, et al. Among authors: hoffmann rm. Nat Commun. 2021 Oct 7;12(1):5885. doi: 10.1038/s41467-021-26163-5. Nat Commun. 2021. PMID: 34620873 Free PMC article.

2

Crystal structure of a lipin/Pah phosphatidic acid phosphatase.

Khayyo VI, Hoffmann RM, Wang H, Bell JA, Burke JE, Reue K, Airola MV. Khayyo VI, et al. Among authors: hoffmann rm. Nat Commun. 2020 Mar 11;11(1):1309. doi: 10.1038/s41467-020-15124-z. Nat Commun. 2020. PMID: 32161260 Free PMC article.

3

Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase.

Khayyo VI, Hoffmann RM, Wang H, Bell JA, Burke JE, Reue K, Airola MV. Khayyo VI, et al. Among authors: hoffmann rm. Nat Commun. 2020 Apr 2;11(1):1734. doi: 10.1038/s41467-020-15509-0. Nat Commun. 2020. PMID: 32242008 Free PMC article.

4

The middle lipin domain adopts a membrane-binding dimeric protein fold.

Gu W, Gao S, Wang H, Fleming KD, Hoffmann RM, Yang JW, Patel NM, Choi YM, Burke JE, Reue K, Airola MV. Gu W, et al. Among authors: hoffmann rm. Nat Commun. 2021 Aug 5;12(1):4718. doi: 10.1038/s41467-021-24929-5. Nat Commun. 2021. PMID: 34354069 Free PMC article.

5

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE. Jenkins ML, et al. Among authors: hoffmann rm. Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z. Nat Commun. 2018. PMID: 30217979 Free PMC article.

6

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.

Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA. Shanbhogue P, et al. Among authors: hoffmann rm. J Biol Chem. 2019 May 3;294(18):7488-7502. doi: 10.1074/jbc.RA118.007288. Epub 2019 Mar 19. J Biol Chem. 2019. PMID: 30890560 Free PMC article.

7

Probing Protein-Membrane Interactions and Dynamics Using Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS).

Stariha JTB, Hoffmann RM, Hamelin DJ, Burke JE. Stariha JTB, et al. Among authors: hoffmann rm. Methods Mol Biol. 2021;2263:465-485. doi: 10.1007/978-1-0716-1197-5_22. Methods Mol Biol. 2021. PMID: 33877613

8

Probing the Architecture, Dynamics, and Inhibition of the PI4KIIIα/TTC7/FAM126 Complex.

Dornan GL, Dalwadi U, Hamelin DJ, Hoffmann RM, Yip CK, Burke JE. Dornan GL, et al. Among authors: hoffmann rm. J Mol Biol. 2018 Sep 14;430(18 Pt B):3129-3142. doi: 10.1016/j.jmb.2018.07.020. Epub 2018 Jul 18. J Mol Biol. 2018. PMID: 30031006

9

Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function.

Seacrist CD, Kuenze G, Hoffmann RM, Moeller BE, Burke JE, Meiler J, Blind RD. Seacrist CD, et al. Among authors: hoffmann rm. Structure. 2020 Jul 7;28(7):830-846.e9. doi: 10.1016/j.str.2020.04.020. Epub 2020 May 19. Structure. 2020. PMID: 32433991 Free PMC article.

10

Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.

Castro-Falcón G, Seiler GS, Demir Ö, Rathinaswamy MK, Hamelin D, Hoffmann RM, Makowski SL, Letzel AC, Field SJ, Burke JE, Amaro RE, Hughes CC. Castro-Falcón G, et al. Among authors: hoffmann rm. J Med Chem. 2018 Dec 13;61(23):10463-10472. doi: 10.1021/acs.jmedchem.8b00975. Epub 2018 Nov 28. J Med Chem. 2018. PMID: 30380865 Free PMC article.

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