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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenco AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, Azouz N, Klingler AM, Rothlauf PW, Thompson CE, Lee M, Klampfer L, Stallings C, Rothenberg ME, Pöhlmann S, Whelan SP, O'Donoghue AJ, Craik CS, Janetka JW. Mahoney M, et al. Among authors: hoffmann m. bioRxiv [Preprint]. 2021 May 6:2021.05.06.442935. doi: 10.1101/2021.05.06.442935. bioRxiv. 2021. PMID: 34131661 Free PMC article. Updated. Preprint.
LY6E impairs coronavirus fusion and confers immune control of viral disease.
Pfaender S, Mar KB, Michailidis E, Kratzel A, Hirt D, V'kovski P, Fan W, Ebert N, Stalder H, Kleine-Weber H, Hoffmann M, Hoffmann HH, Saeed M, Dijkman R, Steinmann E, Wight-Carter M, Hanners NW, Pöhlmann S, Gallagher T, Todt D, Zimmer G, Rice CM, Schoggins JW, Thiel V. Pfaender S, et al. Among authors: hoffmann m, hoffmann hh. bioRxiv [Preprint]. 2020 Mar 7:2020.03.05.979260. doi: 10.1101/2020.03.05.979260. bioRxiv. 2020. PMID: 32511345 Free PMC article. Updated. Preprint.
3,523 results