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Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling.
Holze J, Bermudez M, Pfeil EM, Kauk M, Bödefeld T, Irmen M, Matera C, Dallanoce C, De Amici M, Holzgrabe U, König GM, Tränkle C, Wolber G, Schrage R, Mohr K, Hoffmann C, Kostenis E, Bock A. Holze J, et al. Among authors: hoffmann c. ACS Pharmacol Transl Sci. 2020 Sep 2;3(5):859-867. doi: 10.1021/acsptsci.0c00069. eCollection 2020 Oct 9. ACS Pharmacol Transl Sci. 2020. PMID: 33073186 Free PMC article.
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling.
Bock A, Merten N, Schrage R, Dallanoce C, Bätz J, Klöckner J, Schmitz J, Matera C, Simon K, Kebig A, Peters L, Müller A, Schrobang-Ley J, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K. Bock A, et al. Among authors: hoffmann c. Nat Commun. 2012;3:1044. doi: 10.1038/ncomms2028. Nat Commun. 2012. PMID: 22948826 Free PMC article.
Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.
Bock A, Chirinda B, Krebs F, Messerer R, Bätz J, Muth M, Dallanoce C, Klingenthal D, Tränkle C, Hoffmann C, De Amici M, Holzgrabe U, Kostenis E, Mohr K. Bock A, et al. Among authors: hoffmann c. Nat Chem Biol. 2014 Jan;10(1):18-20. doi: 10.1038/nchembio.1384. Epub 2013 Nov 10. Nat Chem Biol. 2014. PMID: 24212135
A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy.
Agnetta L, Kauk M, Canizal MCA, Messerer R, Holzgrabe U, Hoffmann C, Decker M. Agnetta L, et al. Among authors: hoffmann c. Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7282-7287. doi: 10.1002/anie.201701524. Epub 2017 May 16. Angew Chem Int Ed Engl. 2017. PMID: 28510314
Lack of beta-arrestin signaling in the absence of active G proteins.
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E. Grundmann M, et al. Among authors: hoffmann c. Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3. Nat Commun. 2018. PMID: 29362459 Free PMC article.
Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3.
Heuninck J, Perpiñá Viciano C, Işbilir A, Caspar B, Capoferri D, Briddon SJ, Durroux T, Hill SJ, Lohse MJ, Milligan G, Pin JP, Hoffmann C. Heuninck J, et al. Among authors: hoffmann c. Mol Pharmacol. 2019 Dec;96(6):778-793. doi: 10.1124/mol.118.115477. Epub 2019 May 15. Mol Pharmacol. 2019. PMID: 31092552 Free article. Review.
1,573 results