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CXCL8/CXCR2 signaling mediates bone marrow fibrosis and is a therapeutic target in myelofibrosis.
Dunbar AJ, Kim D, Lu M, Farina M, Bowman RL, Yang JL, Park Y, Karzai A, Xiao W, Zaroogian Z, O'Connor K, Mowla S, Gobbo F, Verachi P, Martelli F, Sarli G, Xia L, Elmansy N, Kleppe M, Chen Z, Xiao Y, McGovern E, Snyder J, Krishnan A, Hill C, Cordner K, Zouak A, Salama ME, Yohai J, Tucker E, Chen J, Zhou J, McConnell T, Migliaccio AR, Koche R, Rampal R, Fan R, Levine RL, Hoffman R. Dunbar AJ, et al. Among authors: hoffman r. Blood. 2023 May 18;141(20):2508-2519. doi: 10.1182/blood.2022015418. Blood. 2023. PMID: 36800567 Free PMC article.
IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms.
Melo-Cardenas J, Bezavada L, Crawford JC, Gurbuxani S, Cotton A, Kang G, Gossett J, Marinaccio C, Weinberg R, Hoffman R, Migliaccio AR, Zheng Y, Derecka M, Rinaldi CR, Crispino JD. Melo-Cardenas J, et al. Among authors: hoffman r. Blood. 2022 Dec 29;140(26):2805-2817. doi: 10.1182/blood.2022017326. Blood. 2022. PMID: 36283106 Free PMC article.
Mapping genotypes to chromatin accessibility profiles in single cells.
Izzo F, Myers RM, Ganesan S, Mekerishvili L, Kottapalli S, Prieto T, Eton EO, Botella T, Dunbar AJ, Bowman RL, Sotelo J, Potenski C, Mimitou EP, Stahl M, El Ghaity-Beckley S, Arandela J, Raviram R, Choi DC, Hoffman R, Chaligné R, Abdel-Wahab O, Smibert P, Ghobrial IM, Scandura JM, Marcellino B, Levine RL, Landau DA. Izzo F, et al. Among authors: hoffman r. Nature. 2024 May 8. doi: 10.1038/s41586-024-07388-y. Online ahead of print. Nature. 2024. PMID: 38720070
Efficacy of Recombinant Methioninase on Late-stage Patient Cancer in the Histoculture Drug Response Assay (HDRA) as a Potential Functional Biomarker of Sensitivity to Methionine-restriction Therapy in the Clinic.
Kubota Y, Sasaki M, Han Q, Hozumi C, Tsunoda T, Hoffman RM. Kubota Y, et al. Among authors: hoffman rm. Cancer Diagn Progn. 2024 May 3;4(3):239-243. doi: 10.21873/cdp.10314. eCollection 2024 May-Jun. Cancer Diagn Progn. 2024. PMID: 38707720 Free PMC article. Review.
Methionine Dependence of Hair Maintenance in C57BL/6 Mice.
Kubota Y, Varshney N, Kobayashi K, Tsunoda T, Hoffman RM. Kubota Y, et al. Among authors: hoffman rm. In Vivo. 2024 May-Jun;38(3):1199-1202. doi: 10.21873/invivo.13555. In Vivo. 2024. PMID: 38688645 Free PMC article.
Targeting Methionine Addiction Combined With Low-dose Irinotecan Arrested Colon Cancer in Contrast to High-dose Irinotecan Alone, Which Was Ineffective, in a Nude-mouse Model.
Sato M, Mizuta K, Han Q, Morinaga S, Kang BM, Kubota Y, Mori R, Baranov A, Kobayashi K, Ardjmand D, Kobayashi N, Bouvet M, Ichikawa Y, Nakajima A, Hoffman RM. Sato M, et al. Among authors: hoffman rm. In Vivo. 2024 May-Jun;38(3):1058-1063. doi: 10.21873/invivo.13539. In Vivo. 2024. PMID: 38688611 Free PMC article.
Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet.
Sato M, Han Q, Mizuta K, Mori R, Kang BM, Morinaga S, Kobayashi N, Ichikawa Y, Nakajima A, Hoffman RM. Sato M, et al. Among authors: hoffman rm. In Vivo. 2024 May-Jun;38(3):1459-1464. doi: 10.21873/invivo.13591. In Vivo. 2024. PMID: 38688589 Free PMC article.
4,425 results