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Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist.
Nichols DP, Morgan SJ, Skalland M, Vo AT, Van Dalfsen JM, Singh SB, Ni W, Hoffman LR, McGeer K, Heltshe SL, Clancy JP, Rowe SM, Jorth P, Singh PK; PROMISE-Micro Study Group. Nichols DP, et al. Among authors: hoffman lr. J Clin Invest. 2023 May 15;133(10):e167957. doi: 10.1172/JCI167957. J Clin Invest. 2023. PMID: 36976651 Free PMC article.
Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections.
Hisert KB, Heltshe SL, Pope C, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, Gallagher CG, Bruce JE, Stoltz DA, Welsh MJ, Hoffman LR, McKone EF, Singh PK. Hisert KB, et al. Among authors: hoffman lr. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1617-1628. doi: 10.1164/rccm.201609-1954OC. Am J Respir Crit Care Med. 2017. PMID: 28222269 Free PMC article.
Human and Extracellular DNA Depletion for Metagenomic Analysis of Complex Clinical Infection Samples Yields Optimized Viable Microbiome Profiles.
Nelson MT, Pope CE, Marsh RL, Wolter DJ, Weiss EJ, Hager KR, Vo AT, Brittnacher MJ, Radey MC, Hayden HS, Eng A, Miller SI, Borenstein E, Hoffman LR. Nelson MT, et al. Among authors: hoffman lr. Cell Rep. 2019 Feb 19;26(8):2227-2240.e5. doi: 10.1016/j.celrep.2019.01.091. Cell Rep. 2019. PMID: 30784601 Free PMC article.
CFTR dysregulation drives active selection of the gut microbiome.
Meeker SM, Mears KS, Sangwan N, Brittnacher MJ, Weiss EJ, Treuting PM, Tolley N, Pope CE, Hager KR, Vo AT, Paik J, Frevert CW, Hayden HS, Hoffman LR, Miller SI, Hajjar AM. Meeker SM, et al. Among authors: hoffman lr. PLoS Pathog. 2020 Jan 21;16(1):e1008251. doi: 10.1371/journal.ppat.1008251. eCollection 2020 Jan. PLoS Pathog. 2020. PMID: 31961914 Free PMC article.
Maintenance tobramycin primarily affects untargeted bacteria in the CF sputum microbiome.
Nelson MT, Wolter DJ, Eng A, Weiss EJ, Vo AT, Brittnacher MJ, Hayden HS, Ravishankar S, Bautista G, Ratjen A, Blackledge M, McNamara S, Nay L, Majors C, Miller SI, Borenstein E, Simon RH, LiPuma JJ, Hoffman LR. Nelson MT, et al. Among authors: hoffman lr. Thorax. 2020 Sep;75(9):780-790. doi: 10.1136/thoraxjnl-2019-214187. Epub 2020 Jul 6. Thorax. 2020. PMID: 32631930 Free PMC article.
134 results