Hoffman HM - Search Results

1

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling.

Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Xian H, et al. Among authors: hoffman hm. Immunity. 2022 Aug 9;55(8):1370-1385.e8. doi: 10.1016/j.immuni.2022.06.007. Epub 2022 Jul 13. Immunity. 2022. PMID: 35835107 Free PMC article.

2

Inflammasome and IL-1beta-mediated disorders.

Hoffman HM, Wanderer AA. Hoffman HM, et al. Curr Allergy Asthma Rep. 2010 Jul;10(4):229-35. doi: 10.1007/s11882-010-0109-z. Curr Allergy Asthma Rep. 2010. PMID: 20425006 Free PMC article. Review.

3

An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury.

Shigeoka AA, Mueller JL, Kambo A, Mathison JC, King AJ, Hall WF, Correia Jda S, Ulevitch RJ, Hoffman HM, McKay DB. Shigeoka AA, et al. Among authors: hoffman hm. J Immunol. 2010 Nov 15;185(10):6277-85. doi: 10.4049/jimmunol.1002330. Epub 2010 Oct 20. J Immunol. 2010. PMID: 20962258 Free PMC article.

4

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE. Wree A, et al. Among authors: hoffman hm. Hepatology. 2014 Mar;59(3):898-910. doi: 10.1002/hep.26592. Epub 2014 Jan 30. Hepatology. 2014. PMID: 23813842 Free PMC article.

5

NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE. Wree A, et al. Among authors: hoffman hm. J Mol Med (Berl). 2014 Oct;92(10):1069-82. doi: 10.1007/s00109-014-1170-1. Epub 2014 May 28. J Mol Med (Berl). 2014. PMID: 24861026 Free PMC article.

6

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.

Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T. Yu J, et al. Among authors: hoffman hm. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15514-9. doi: 10.1073/pnas.1414859111. Epub 2014 Oct 13. Proc Natl Acad Sci U S A. 2014. PMID: 25313054 Free PMC article.

7

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.

Toldo S, Mezzaroma E, McGeough MD, Peña CA, Marchetti C, Sonnino C, Van Tassell BW, Salloum FN, Voelkel NF, Hoffman HM, Abbate A. Toldo S, et al. Among authors: hoffman hm. Cardiovasc Res. 2015 Feb 1;105(2):203-12. doi: 10.1093/cvr/cvu259. Epub 2014 Dec 18. Cardiovasc Res. 2015. PMID: 25524927 Free PMC article.

8

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

de Almeida L, Khare S, Misharin AV, Patel R, Ratsimandresy RA, Wallin MC, Perlman H, Greaves DR, Hoffman HM, Dorfleutner A, Stehlik C. de Almeida L, et al. Among authors: hoffman hm. Immunity. 2015 Aug 18;43(2):264-76. doi: 10.1016/j.immuni.2015.07.018. Epub 2015 Aug 11. Immunity. 2015. PMID: 26275995 Free PMC article.

9

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. Zhong Z, et al. Among authors: hoffman hm. Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057. Cell. 2016. PMID: 26919428 Free PMC article.

10

IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.

Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS. Stouch AN, et al. Among authors: hoffman hm. J Immunol. 2016 Apr 15;196(8):3411-20. doi: 10.4049/jimmunol.1500906. Epub 2016 Mar 7. J Immunol. 2016. PMID: 26951798 Free PMC article.

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