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Inhibition of the NLRP3 inflammasome prevents ovarian aging.
Navarro-Pando JM, Alcocer-Gómez E, Castejón-Vega B, Navarro-Villarán E, Condés-Hervás M, Mundi-Roldan M, Muntané J, Pérez-Pulido AJ, Bullon P, Wang C, Hoffman HM, Sanz A, Mbalaviele G, Ryffel B, Cordero MD. Navarro-Pando JM, et al. Among authors: hoffman hm. Sci Adv. 2021 Jan 1;7(1):eabc7409. doi: 10.1126/sciadv.abc7409. Print 2021 Jan. Sci Adv. 2021. PMID: 33523841 Free PMC article.
Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.
Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G. Bonar SL, et al. Among authors: hoffman hm. PLoS One. 2012;7(4):e35979. doi: 10.1371/journal.pone.0035979. Epub 2012 Apr 27. PLoS One. 2012. PMID: 22558291 Free PMC article.
NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. Qu C, et al. Among authors: hoffman hm. FASEB J. 2015 Apr;29(4):1269-79. doi: 10.1096/fj.14-264804. Epub 2014 Dec 4. FASEB J. 2015. PMID: 25477279 Free PMC article.
Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G. Wang C, et al. Among authors: hoffman hm. J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16. J Exp Med. 2018. PMID: 29549113 Free PMC article.
NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE. Wree A, et al. Among authors: hoffman hm. J Mol Med (Berl). 2014 Oct;92(10):1069-82. doi: 10.1007/s00109-014-1170-1. Epub 2014 May 28. J Mol Med (Berl). 2014. PMID: 24861026 Free PMC article.
NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice.
Wree A, McGeough MD, Inzaugarat ME, Eguchi A, Schuster S, Johnson CD, Peña CA, Geisler LJ, Papouchado BG, Hoffman HM, Feldstein AE. Wree A, et al. Among authors: hoffman hm. Hepatology. 2018 Feb;67(2):736-749. doi: 10.1002/hep.29523. Epub 2017 Dec 28. Hepatology. 2018. PMID: 28902427 Free PMC article.
180 results