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Novel humanin analogs confer neuroprotection and myoprotection to neuronal and myoblast cell cultures exposed to ischemia-like and doxorubicin-induced cell death insults.
Gilon C, Gitlin-Domagalska A, Lahiani A, Yehoshua-Alshanski S, Shumacher-Klinger A, Gilon D, Taha M, Sekler I, Hoffman A, Lazarovici P. Gilon C, et al. Among authors: hoffman a. Peptides. 2020 Dec;134:170399. doi: 10.1016/j.peptides.2020.170399. Epub 2020 Sep 1. Peptides. 2020. PMID: 32889021
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity.
Hess S, Linde Y, Ovadia O, Safrai E, Shalev DE, Swed A, Halbfinger E, Lapidot T, Winkler I, Gabinet Y, Faier A, Yarden D, Xiang Z, Portillo FP, Haskell-Luevano C, Gilon C, Hoffman A. Hess S, et al. Among authors: hoffman a. J Med Chem. 2008 Feb 28;51(4):1026-34. doi: 10.1021/jm701093y. Epub 2008 Jan 26. J Med Chem. 2008. PMID: 18220330
Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: the HIV-1 CD4:gp120 paradigm.
Hurevich M, Swed A, Joubran S, Cohen S, Freeman NS, Britan-Rosich E, Briant-Longuet L, Bardy M, Devaux C, Kotler M, Hoffman A, Gilon C. Hurevich M, et al. Among authors: hoffman a. Bioorg Med Chem. 2010 Aug 1;18(15):5754-61. doi: 10.1016/j.bmc.2010.04.053. Epub 2010 Apr 21. Bioorg Med Chem. 2010. PMID: 20619663
2,326 results