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Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine.
J Org Chem. 2019 Jun 21;84(12):8006-8018. doi: 10.1021/acs.joc.9b00569. Epub 2019 Jun 5.
J Org Chem. 2019.
PMID: 31124362
Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine.
Xu F, Zacuto M, Yoshikawa N, Desmond R, Hoerrner S, Itoh T, Journet M, Humphrey GR, Cowden C, Strotman N, Devine P.
Xu F, et al. Among authors: hoerrner s.
J Org Chem. 2010 Nov 19;75(22):7829-41. doi: 10.1021/jo101704b. Epub 2010 Oct 18.
J Org Chem. 2010.
PMID: 20954694
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Remote electronic control in the regioselective reduction of succinimides: a practical, scalable synthesis of Ep4 antagonist MF-310.
Molinaro C, Gauvreau D, Hughes G, Lau S, Lauzon S, Angelaud R, O'Shea PD, Janey J, Palucki M, Hoerrner SR, Raab CE, Sidler RR, Belley M, Han Y.
Molinaro C, et al. Among authors: hoerrner sr.
J Org Chem. 2009 Sep 4;74(17):6863-6. doi: 10.1021/jo901267x.
J Org Chem. 2009.
PMID: 19663395
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