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Page 1
Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia.
Sabri O, Meyer PM, Gräf S, Hesse S, Wilke S, Becker GA, Rullmann M, Patt M, Luthardt J, Wagenknecht G, Hoepping A, Smits R, Franke A, Sattler B, Tiepolt S, Fischer S, Deuther-Conrad W, Hegerl U, Barthel H, Schönknecht P, Brust P. Sabri O, et al. Among authors: hoepping a. Brain. 2018 Jun 1;141(6):1840-1854. doi: 10.1093/brain/awy099. Brain. 2018. PMID: 29672680 Free PMC article.
LC-MS Supported Studies on the in Vitro Metabolism of both Enantiomers of Flubatine and the in Vivo Metabolism of (+)-[(18)F]Flubatine-A Positron Emission Tomography Radioligand for Imaging α4β2 Nicotinic Acetylcholine Receptors.
Ludwig FA, Smits R, Fischer S, Donat CK, Hoepping A, Brust P, Steinbach J. Ludwig FA, et al. Among authors: hoepping a. Molecules. 2016 Sep 8;21(9):1200. doi: 10.3390/molecules21091200. Molecules. 2016. PMID: 27617996 Free PMC article.
(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand-results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer's disease and healthy controls.
Tiepolt S, Becker GA, Wilke S, Cecchin D, Rullmann M, Meyer PM, Barthel H, Hesse S, Patt M, Luthardt J, Wagenknecht G, Sattler B, Deuther-Conrad W, Ludwig FA, Fischer S, Gertz HJ, Smits R, Hoepping A, Steinbach J, Brust P, Sabri O. Tiepolt S, et al. Among authors: hoepping a. Eur J Nucl Med Mol Imaging. 2021 Mar;48(3):731-746. doi: 10.1007/s00259-020-05029-w. Epub 2020 Sep 16. Eur J Nucl Med Mol Imaging. 2021. PMID: 32935187 Free PMC article.
Synthesis and biological evaluation of both enantiomers of [(18)F]flubatine, promising radiotracers with fast kinetics for the imaging of α4β2-nicotinic acetylcholine receptors.
Smits R, Fischer S, Hiller A, Deuther-Conrad W, Wenzel B, Patt M, Cumming P, Steinbach J, Sabri O, Brust P, Hoepping A. Smits R, et al. Among authors: hoepping a. Bioorg Med Chem. 2014 Jan 15;22(2):804-12. doi: 10.1016/j.bmc.2013.12.011. Epub 2013 Dec 12. Bioorg Med Chem. 2014. PMID: 24369841
Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (-)-[(18)F]Flubatine in humans.
Patt M, Becker GA, Grossmann U, Habermann B, Schildan A, Wilke S, Deuther-Conrad W, Graef S, Fischer S, Smits R, Hoepping A, Wagenknecht G, Steinbach J, Gertz HJ, Hesse S, Schönknecht P, Brust P, Sabri O. Patt M, et al. Among authors: hoepping a. Nucl Med Biol. 2014 Jul;41(6):489-94. doi: 10.1016/j.nucmedbio.2014.03.018. Epub 2014 Mar 29. Nucl Med Biol. 2014. PMID: 24768146
First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (-)-[(18)F]Flubatine.
Sabri O, Becker GA, Meyer PM, Hesse S, Wilke S, Graef S, Patt M, Luthardt J, Wagenknecht G, Hoepping A, Smits R, Franke A, Sattler B, Habermann B, Neuhaus P, Fischer S, Tiepolt S, Deuther-Conrad W, Barthel H, Schönknecht P, Brust P. Sabri O, et al. Among authors: hoepping a. Neuroimage. 2015 Sep;118:199-208. doi: 10.1016/j.neuroimage.2015.05.065. Epub 2015 May 30. Neuroimage. 2015. PMID: 26037057
Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results.
Kranz M, Sattler B, Tiepolt S, Wilke S, Deuther-Conrad W, Donat CK, Fischer S, Patt M, Schildan A, Patt J, Smits R, Hoepping A, Steinbach J, Sabri O, Brust P. Kranz M, et al. Among authors: hoepping a. EJNMMI Phys. 2016 Dec;3(1):25. doi: 10.1186/s40658-016-0160-5. Epub 2016 Oct 21. EJNMMI Phys. 2016. PMID: 27770429 Free PMC article.
In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine - A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET).
Ludwig FA, Fischer S, Houska R, Hoepping A, Deuther-Conrad W, Schepmann D, Patt M, Meyer PM, Hesse S, Becker GA, Zientek FR, Steinbach J, Wünsch B, Sabri O, Brust P. Ludwig FA, et al. Among authors: hoepping a. Front Pharmacol. 2019 Jun 13;10:534. doi: 10.3389/fphar.2019.00534. eCollection 2019. Front Pharmacol. 2019. PMID: 31263411 Free PMC article.
35 results