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Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis.
Herold T, Schneider S, Metzeler KH, Neumann M, Hartmann L, Roberts KG, Konstandin NP, Greif PA, Bräundl K, Ksienzyk B, Huk N, Schneider I, Zellmeier E, Jurinovic V, Mansmann U, Hiddemann W, Mullighan CG, Bohlander SK, Spiekermann K, Hoelzer D, Brüggemann M, Baldus CD, Dreyling M, Gökbuget N. Herold T, et al. Among authors: hoelzer d. Haematologica. 2017 Jan;102(1):130-138. doi: 10.3324/haematol.2015.136366. Epub 2016 Aug 25. Haematologica. 2017. PMID: 27561722 Free PMC article.
Treatment of adult acute lymphoblastic leukemia.
Gökbuget N, Hoelzer D. Gökbuget N, et al. Among authors: hoelzer d. Hematology Am Soc Hematol Educ Program. 2006:133-41. doi: 10.1182/asheducation-2006.1.133. Hematology Am Soc Hematol Educ Program. 2006. PMID: 17124052 Review.
Treatment of adult acute lymphoblastic leukemia.
Gökbuget N, Hoelzer D. Gökbuget N, et al. Among authors: hoelzer d. Semin Hematol. 2009 Jan;46(1):64-75. doi: 10.1053/j.seminhematol.2008.09.003. Semin Hematol. 2009. PMID: 19100369 Review.
CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy.
Fischer L, Gökbuget N, Schwartz S, Burmeister T, Rieder H, Brüggemann M, Hoelzer D, Thiel E. Fischer L, et al. Among authors: hoelzer d. Haematologica. 2009 Feb;94(2):224-9. doi: 10.3324/haematol.13543. Epub 2008 Dec 23. Haematologica. 2009. PMID: 19109214 Free PMC article.
Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia.
Heesch S, Goekbuget N, Stroux A, Tanchez JO, Schlee C, Burmeister T, Schwartz S, Blau O, Keilholz U, Busse A, Hoelzer D, Thiel E, Hofmann WK, Baldus CD. Heesch S, et al. Among authors: hoelzer d. Haematologica. 2010 Jun;95(6):942-9. doi: 10.3324/haematol.2009.016386. Epub 2010 Apr 30. Haematologica. 2010. PMID: 20435628 Free PMC article.
Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia.
Kobitzsch B, Gökbuget N, Schwartz S, Reinhardt R, Brüggemann M, Viardot A, Wäsch R, Starck M, Thiel E, Hoelzer D, Burmeister T. Kobitzsch B, et al. Among authors: hoelzer d. Haematologica. 2017 Oct;102(10):1739-1747. doi: 10.3324/haematol.2016.161273. Epub 2017 Jul 27. Haematologica. 2017. PMID: 28751559 Free PMC article.
Recent approaches in acute lymphoblastic leukemia in adults.
Gökbuget N, Hoelzer D. Gökbuget N, et al. Among authors: hoelzer d. Rev Clin Exp Hematol. 2002 Jun;6(2):114-41; discussion 200-2. doi: 10.1046/j.1468-0734.2002.00068.x. Rev Clin Exp Hematol. 2002. PMID: 12196212 Review.
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