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Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.
Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Berbée JF, et al. Among authors: hoeke g. Nat Commun. 2015 Mar 10;6:6356. doi: 10.1038/ncomms7356. Nat Commun. 2015. PMID: 25754609 Free PMC article.
Brown adipose tissue takes up plasma triglycerides mostly after lipolysis.
Khedoe PP, Hoeke G, Kooijman S, Dijk W, Buijs JT, Kersten S, Havekes LM, Hiemstra PS, Berbée JF, Boon MR, Rensen PC. Khedoe PP, et al. Among authors: hoeke g. J Lipid Res. 2015 Jan;56(1):51-9. doi: 10.1194/jlr.M052746. Epub 2014 Oct 28. J Lipid Res. 2015. PMID: 25351615 Free PMC article.
The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.
Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, Dib LH, Mol IM, Caengprasath N, Chan YW, Damak S, Miller AR, Coskun T, Shimpukade B, Ulven T, Kooijman S, Rensen PC, Christian M. Schilperoort M, et al. Among authors: hoeke g. EMBO Mol Med. 2018 Mar;10(3):e8047. doi: 10.15252/emmm.201708047. EMBO Mol Med. 2018. PMID: 29343498 Free PMC article.
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