Hoch U - Search Results

1

Horseradish Peroxidase-Catalyzed Enantioselective Reduction of Racemic Hydroperoxy Homoallylic Alcohols: A Novel Enzymatic Method for the Preparation of Optically Active, Unsaturated Diols and Hydroperoxy Alcohols.

Adam W, Lazarus M, Hoch U, Korb MN, Saha-Möller CR, Schreier P. Adam W, et al. Among authors: hoch u. J Org Chem. 1998 Sep 4;63(18):6123-6127. doi: 10.1021/jo980028h. J Org Chem. 1998. PMID: 11672239

2

Biotransformations with peroxidases.

Adam W, Lazarus M, Saha-Möller CR, Weichold O, Hoch U, Häring D, Schreier P. Adam W, et al. Among authors: hoch u. Adv Biochem Eng Biotechnol. 1999;63:73-108. doi: 10.1007/3-540-69791-8_4. Adv Biochem Eng Biotechnol. 1999. PMID: 9933982 Review.

3

Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family.

LeBrun LA, Hoch U, Ortiz de Montellano PR. LeBrun LA, et al. Among authors: hoch u. J Biol Chem. 2002 Apr 12;277(15):12755-61. doi: 10.1074/jbc.M112155200. Epub 2002 Jan 30. J Biol Chem. 2002. PMID: 11821421 Free article.

4

Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.

Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR. Hoch U, et al. Arch Biochem Biophys. 2000 Jan 1;373(1):63-71. doi: 10.1006/abbi.1999.1504. Arch Biochem Biophys. 2000. PMID: 10620324

5

Covalently linked heme in cytochrome p4504a fatty acid hydroxylases.

Hoch U, Ortiz De Montellano PR. Hoch U, et al. J Biol Chem. 2001 Apr 6;276(14):11339-46. doi: 10.1074/jbc.M009969200. Epub 2001 Jan 3. J Biol Chem. 2001. PMID: 11139583 Free article.

6

EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme.

Ogura H, Nishida CR, Hoch UR, Perera R, Dawson JH, Ortiz de Montellano PR. Ogura H, et al. Biochemistry. 2004 Nov 23;43(46):14712-21. doi: 10.1021/bi048980d. Biochemistry. 2004. PMID: 15544342

7

Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases.

Hoch U, Falck JR, de Montellano PR. Hoch U, et al. J Biol Chem. 2000 Sep 1;275(35):26952-8. doi: 10.1074/jbc.M004841200. J Biol Chem. 2000. PMID: 10869363 Free article.

A previous study of chimeras of the rat CYP4A2 and CYP4A3 enzymes established that the regiochemistry of fatty acid hydroxylation is determined by the first 119 amino acid residues (Hoch, U., Zhang. Z. P., Kroetz, D. L., and Ortiz de Montellano, P. ...

A previous study of chimeras of the rat CYP4A2 and CYP4A3 enzymes established that the regiochemistry of fatty acid hydroxylation is determi …

8

Metabolism of (+)-1,4-dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid (voreloxin; formerly SNS-595), a novel replication-dependent DNA-damaging agent.

Evanchik MJ, Allen D, Yoburn JC, Silverman JA, Hoch U. Evanchik MJ, et al. Among authors: hoch u. Drug Metab Dispos. 2009 Mar;37(3):594-601. doi: 10.1124/dmd.108.023432. Epub 2008 Dec 12. Drug Metab Dispos. 2009. PMID: 19074528

9

A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.

Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U. Choong IC, et al. Among authors: hoch u. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5. doi: 10.1016/j.bmcl.2008.09.073. Epub 2008 Sep 24. Bioorg Med Chem Lett. 2008. PMID: 18842409

10

Discovery of a potent and selective aurora kinase inhibitor.

Oslob JD, Romanowski MJ, Allen DA, Baskaran S, Bui M, Elling RA, Flanagan WM, Fung AD, Hanan EJ, Harris S, Heumann SA, Hoch U, Jacobs JW, Lam J, Lawrence CE, McDowell RS, Nannini MA, Shen W, Silverman JA, Sopko MM, Tangonan BT, Teague J, Yoburn JC, Yu CH, Zhong M, Zimmerman KM, O'Brien T, Lew W. Oslob JD, et al. Among authors: hoch u. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. doi: 10.1016/j.bmcl.2008.07.073. Epub 2008 Jul 24. Bioorg Med Chem Lett. 2008. PMID: 18678489

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