Hobrath JV - Search Results

1

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

Slominski AT, Kim TK, Hobrath JV, Oak ASW, Tang EKY, Tieu EW, Li W, Tuckey RC, Jetten AM. Slominski AT, et al. Among authors: hobrath jv. J Steroid Biochem Mol Biol. 2017 Oct;173:42-56. doi: 10.1016/j.jsbmb.2016.09.024. Epub 2016 Sep 28. J Steroid Biochem Mol Biol. 2017. PMID: 27693422 Free PMC article. Review.

2

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols.

Slominski AT, Kim TK, Hobrath JV, Janjetovic Z, Oak ASW, Postlethwaite A, Lin Z, Li W, Takeda Y, Jetten AM, Tuckey RC. Slominski AT, et al. Among authors: hobrath jv. Sci Rep. 2017 Sep 12;7(1):11434. doi: 10.1038/s41598-017-10202-7. Sci Rep. 2017. PMID: 28900196 Free PMC article.

3

Slow-Binding Inhibition of Mycobacterium tuberculosis Shikimate Kinase by Manzamine Alkaloids.

Simithy J, Fuanta NR, Alturki M, Hobrath JV, Wahba AE, Pina I, Rath J, Hamann MT, DeRuiter J, Goodwin DC, Calderón AI. Simithy J, et al. Among authors: hobrath jv. Biochemistry. 2018 Aug 14;57(32):4923-4933. doi: 10.1021/acs.biochem.8b00231. Epub 2018 Jul 31. Biochemistry. 2018. PMID: 30063132

4

Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.

Ananthan S, Saini SK, Zhou G, Hobrath JV, Padmalayam I, Zhai L, Bostwick JR, Antonio T, Reith ME, McDowell S, Cho E, McAleer L, Taylor M, Luedtke RR. Ananthan S, et al. Among authors: hobrath jv. J Med Chem. 2014 Aug 28;57(16):7042-60. doi: 10.1021/jm500801r. Epub 2014 Aug 15. J Med Chem. 2014. PMID: 25126833 Free PMC article.

5

Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis.

Mathew B, Hobrath JV, Ross L, Connelly MC, Lofton H, Rajagopalan M, Guy RK, Reynolds RC. Mathew B, et al. Among authors: hobrath jv. PLoS One. 2016 Oct 21;11(10):e0164100. doi: 10.1371/journal.pone.0164100. eCollection 2016. PLoS One. 2016. PMID: 27768711 Free PMC article.

6

Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.

Manuvakhova MS, Johnson GG, White MC, Ananthan S, Sosa M, Maddox C, McKellip S, Rasmussen L, Wennerberg K, Hobrath JV, White EL, Maddry JA, Grimaldi M. Manuvakhova MS, et al. Among authors: hobrath jv. J Neurosci Res. 2011 Jan;89(1):58-72. doi: 10.1002/jnr.22526. J Neurosci Res. 2011. PMID: 21046675 Free PMC article.

7

Chemical insights into the search for MAIT cells activators.

Veerapen N, Hobrath J, Besra AK, Besra GS. Veerapen N, et al. Mol Immunol. 2021 Jan;129:114-120. doi: 10.1016/j.molimm.2020.11.017. Epub 2020 Dec 6. Mol Immunol. 2021. PMID: 33293098 Free article. Review.

8

A multifaceted approach to identify non-specific enzyme inhibition: Application to Mycobacterium tuberculosis shikimate kinase.

Alturki MS, Fuanta NR, Jarrard MA, Hobrath JV, Goodwin DC, Rants'o TA, Calderón AI. Alturki MS, et al. Among authors: hobrath jv. Bioorg Med Chem Lett. 2018 Feb 15;28(4):802-808. doi: 10.1016/j.bmcl.2017.12.002. Epub 2017 Dec 5. Bioorg Med Chem Lett. 2018. PMID: 29366649 Free article.

9

Diverse amide analogs of sulindac for cancer treatment and prevention.

Mathew B, Hobrath JV, Connelly MC, Kiplin Guy R, Reynolds RC. Mathew B, et al. Among authors: hobrath jv. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4614-4621. doi: 10.1016/j.bmcl.2017.09.022. Epub 2017 Sep 13. Bioorg Med Chem Lett. 2017. PMID: 28935266 Free PMC article.

10

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens.

Mathew B, Hobrath JV, Lu W, Li Y, Reynolds RC. Mathew B, et al. Among authors: hobrath jv. Med Chem Res. 2017;26(11):3038-3045. doi: 10.1007/s00044-017-2001-z. Epub 2017 Aug 5. Med Chem Res. 2017. PMID: 29104411 Free PMC article.

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